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The relationship between metabolic syndrome and the incidence of colorectal cancer

Authors
 JungHyun Lee  ;  Kun Sei Lee  ;  Hyeongsu Kim  ;  Hyoseon Jeong  ;  Min-Jung Choi  ;  Hai-Won Yoo  ;  Tae-Hwa Han  ;  Hyunjung Lee 
Citation
 ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, Vol.25(1) : 6, 2020-02 
Journal Title
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
ISSN
 1342-078X 
Issue Date
2020-02
MeSH
Adult ; Aged ; Colorectal Neoplasms / epidemiology* ; Colorectal Neoplasms / etiology ; Female ; Humans ; Incidence ; Male ; Metabolic Syndrome / epidemiology* ; Metabolic Syndrome / etiology ; Middle Aged ; Proportional Hazards Models ; Republic of Korea / epidemiology ; Risk Factors
Keywords
Metabolic syndrome ; Colorectal cancer ; Relevance ; Koreans
Abstract
Objectives This study evaluated the incidence of colorectal cancer (CRC) according to the number of metabolic syndrome (MetS) components. Methods Using health checkup and insurance claims data of 6,365,409 subjects, the occurrence of CRC according to stage of MetS by sex was determined from the date of the health checkup in 2009 until December 31, 2018. Results Cumulative incidence rates (CIR) of CRC in men and women was 3.9 and 2.8 per 1000 (p < 0.001), respectively. CIR of CRC for the normal, pre-MetS, and MetS groups in men was 2.6, 3.9, and 5.5 per 1000 (p < 0.001) and CIR in women was 2.1, 2.9, and 4.5 per 1000 (p < 0.001), respectively. Compared with the normal group, the hazard ratio (HR) of CRC for the pre-MetS group was 1.25 (95% CI 1.17-1.33) in men and 1.09 (95% CI 1.02-1.17) in women, and the HR of CRC for the MetS group was 1.54 (95% CI 1.43-1.65) in men and 1.39 (95% CI 1.26-1.53) in women after adjustment. Conclusions We found that MetS is a risk factor for CRC in this study. Therefore, the prevention and active management of MetS would contribute to the prevention of CRC.
Files in This Item:
T9992020490.pdf Download
DOI
10.1186/s12199-020-00845-w
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
Yonsei Authors
Han, Taehwa(한태화)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190265
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