0 51

Cited 0 times in

Ultrastructural evidence of the evolutional process in malakoplakia

Authors
 Yeon Seung Jung  ;  Dong Yong Chung  ;  Eun Jin Kim  ;  Nam Hoon Cho 
Citation
 HISTOLOGY AND HISTOPATHOLOGY, Vol.35(2) : 177-184, 2020-02 
Journal Title
HISTOLOGY AND HISTOPATHOLOGY
ISSN
 0213-3911 
Issue Date
2020-02
MeSH
Aged ; Escherichia coli ; Escherichia coli Infections / pathology* ; Female ; Humans ; Inclusion Bodies / microbiology ; Inclusion Bodies / pathology ; Inclusion Bodies / ultrastructure* ; Lysosomes / ultrastructure ; Malacoplakia / microbiology* ; Malacoplakia / pathology* ; Male ; Microscopy, Electron ; Prostate / pathology ; Prostate / ultrastructure ; Urinary Bladder / pathology ; Urinary Bladder / ultrastructure
Keywords
Malakoplakia ; Michaelis-Gutmann body ; E. coli ; Xanthogranulomatous pyelonephritis ; Transmission electron microscope ; Scanning electron microscope
Abstract
Context. Malakoplakia can be caused by incomplete digestion of Escherichia coli by lysosomes, leading to recurrent urinary tract infections and consequential mass-forming events that mimic tumors. Objectives. By using ultrastructural findings, we aimed to specify the process of phagolysosome to evoke malakoplakia. Design. We observed a series of processes to form a peculiar Michaelis-Gutmann (MG) body in three patients with malakoplakia and compared with xanthogranulomatous pyelonephritis. Results. The ultrastructural findings were realigned according to the sequence of events as pre-phagosomal, phagosomal, and post-phagosomal stages. For the mature MG body, numerous lysosomal aggregates targeting pathogens and subsequent incomplete digestion are prerequisite factors for the pre-phagosomal stage. Scattered lamellated residue is late evidence of the prephagosomal stage. Phagosomes can be formed by the fusion of multiple pathogens and multiple lysosomes. We utilized transmission and scanning electron microscopy to speculate on the process of phagolysosomal formation. Conclusion. The recognition of E. coli captured by phagosomes or partially damaged by lysosomal attack within the cell was recorded for the first time. Furthermore, SEM observation was performed on human tissue.
Full Text
https://www.hh.um.es/Abstracts/Vol_35/35_2/35_2_177.htm
DOI
10.14670/HH-18-150
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Chung, Yeon Seung(정연승)
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190218
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links