Cited 8 times in
Ultrastructural evidence of the evolutional process in malakoplakia
DC Field | Value | Language |
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dc.contributor.author | 정연승 | - |
dc.contributor.author | 조남훈 | - |
dc.date.accessioned | 2022-09-06T06:35:04Z | - |
dc.date.available | 2022-09-06T06:35:04Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190218 | - |
dc.description.abstract | Context. Malakoplakia can be caused by incomplete digestion of Escherichia coli by lysosomes, leading to recurrent urinary tract infections and consequential mass-forming events that mimic tumors. Objectives. By using ultrastructural findings, we aimed to specify the process of phagolysosome to evoke malakoplakia. Design. We observed a series of processes to form a peculiar Michaelis-Gutmann (MG) body in three patients with malakoplakia and compared with xanthogranulomatous pyelonephritis. Results. The ultrastructural findings were realigned according to the sequence of events as pre-phagosomal, phagosomal, and post-phagosomal stages. For the mature MG body, numerous lysosomal aggregates targeting pathogens and subsequent incomplete digestion are prerequisite factors for the pre-phagosomal stage. Scattered lamellated residue is late evidence of the prephagosomal stage. Phagosomes can be formed by the fusion of multiple pathogens and multiple lysosomes. We utilized transmission and scanning electron microscopy to speculate on the process of phagolysosomal formation. Conclusion. The recognition of E. coli captured by phagosomes or partially damaged by lysosomal attack within the cell was recorded for the first time. Furthermore, SEM observation was performed on human tissue. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Histology and Histopathology | - |
dc.relation.isPartOf | HISTOLOGY AND HISTOPATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Escherichia coli | - |
dc.subject.MESH | Escherichia coli Infections / pathology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inclusion Bodies / microbiology | - |
dc.subject.MESH | Inclusion Bodies / pathology | - |
dc.subject.MESH | Inclusion Bodies / ultrastructure* | - |
dc.subject.MESH | Lysosomes / ultrastructure | - |
dc.subject.MESH | Malacoplakia / microbiology* | - |
dc.subject.MESH | Malacoplakia / pathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microscopy, Electron | - |
dc.subject.MESH | Prostate / pathology | - |
dc.subject.MESH | Prostate / ultrastructure | - |
dc.subject.MESH | Urinary Bladder / pathology | - |
dc.subject.MESH | Urinary Bladder / ultrastructure | - |
dc.title | Ultrastructural evidence of the evolutional process in malakoplakia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Yeon Seung Jung | - |
dc.contributor.googleauthor | Dong Yong Chung | - |
dc.contributor.googleauthor | Eun Jin Kim | - |
dc.contributor.googleauthor | Nam Hoon Cho | - |
dc.identifier.doi | 10.14670/HH-18-150 | - |
dc.contributor.localId | A06154 | - |
dc.contributor.localId | A03812 | - |
dc.relation.journalcode | J00993 | - |
dc.identifier.eissn | 1699-5848 | - |
dc.identifier.pmid | 31298302 | - |
dc.identifier.url | https://www.hh.um.es/Abstracts/Vol_35/35_2/35_2_177.htm | - |
dc.subject.keyword | Malakoplakia | - |
dc.subject.keyword | Michaelis-Gutmann body | - |
dc.subject.keyword | E. coli | - |
dc.subject.keyword | Xanthogranulomatous pyelonephritis | - |
dc.subject.keyword | Transmission electron microscope | - |
dc.subject.keyword | Scanning electron microscope | - |
dc.contributor.alternativeName | Chung, Yeon Seung | - |
dc.contributor.affiliatedAuthor | 정연승 | - |
dc.contributor.affiliatedAuthor | 조남훈 | - |
dc.citation.volume | 35 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 177 | - |
dc.citation.endPage | 184 | - |
dc.identifier.bibliographicCitation | HISTOLOGY AND HISTOPATHOLOGY, Vol.35(2) : 177-184, 2020-02 | - |
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