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Assessing the progression of gastric cancer via profiling of histamine, histidine, and bile acids in gastric juice using LC-MS/MS

Authors
 Wonwoong Lee  ;  Jinhee Um  ;  Boram Hwang  ;  Yong Chan Lee  ;  Bong Chul Chung  ;  Jongki Hong 
Citation
 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, Vol.197 : 105539, 2020-03 
Journal Title
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
ISSN
 0960-0760 
Issue Date
2020-03
MeSH
Bile Acids and Salts / analysis* ; Bile Acids and Salts / metabolism ; Chromatography, Liquid / methods ; Disease Progression ; Gastric Juice / metabolism* ; Histamine / analysis* ; Histamine / metabolism ; Histidine / analysis* ; Histidine / metabolism ; Humans ; Metaplasia / metabolism ; Metaplasia / pathology* ; Precancerous Conditions / metabolism ; Precancerous Conditions / pathology* ; Stomach Neoplasms / metabolism ; Stomach Neoplasms / pathology* ; Tandem Mass Spectrometry / methods
Keywords
Bile acids ; Histidine decarboxylase ; LC-MS/MS ; Gut microbiome ; Gastric juice ; Gastric cancer
Abstract
Bile acid (BA) imbalance may be directly associated with gastric cancer and indirectly influence stomach carcinogenesis via overexpression of histidine decarboxylase (HDC), which converts histidine (His) into histamine (HIST). Moreover, the progression of gastric cancer, could change the gut microbiome, including bacteria spp. that produce secondary BAs. Gastric juice has various metabolites that could indicate gastric cancer-related stomach conditions. Therefore, profiling of HIST, His, and BM in gastric juice is crucial for understanding the etiological mechanisms of gastric cancer. We used a profiling method to simultaneously determine targeted metabolites in gastric juice using liquid chromatography-tandem mass spectrometry (LC-MS/MS). We successfully analyzed 70 human gastric juice samples from patients with chronic superficial gastritis (CSG, n = 20), intestinal metaplasia (IM, n = 12), and gastric cancer (n = 38). Furthermore, we investigated the relevance between BA metabolism and gastric cancer. There were statistical differences in the metabolism of cholic acid (CA) into deoxycholic acid (DCA) based on the progression of CSG into IM and gastric cancer. Hence, the progression of gastric cancer might be related to the alterations in gut microbiome composition. We provide insight into the etiological mechanisms of the progression of gastric cancer and biomarkers to diagnose and treat gastric cancer.
Full Text
https://www.sciencedirect.com/science/article/pii/S0960076019304972
DOI
10.1016/j.jsbmb.2019.105539
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190205
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