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Assessing the progression of gastric cancer via profiling of histamine, histidine, and bile acids in gastric juice using LC-MS/MS

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dc.contributor.author이용찬-
dc.date.accessioned2022-09-06T06:08:38Z-
dc.date.available2022-09-06T06:08:38Z-
dc.date.issued2020-03-
dc.identifier.issn0960-0760-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/190205-
dc.description.abstractBile acid (BA) imbalance may be directly associated with gastric cancer and indirectly influence stomach carcinogenesis via overexpression of histidine decarboxylase (HDC), which converts histidine (His) into histamine (HIST). Moreover, the progression of gastric cancer, could change the gut microbiome, including bacteria spp. that produce secondary BAs. Gastric juice has various metabolites that could indicate gastric cancer-related stomach conditions. Therefore, profiling of HIST, His, and BM in gastric juice is crucial for understanding the etiological mechanisms of gastric cancer. We used a profiling method to simultaneously determine targeted metabolites in gastric juice using liquid chromatography-tandem mass spectrometry (LC-MS/MS). We successfully analyzed 70 human gastric juice samples from patients with chronic superficial gastritis (CSG, n = 20), intestinal metaplasia (IM, n = 12), and gastric cancer (n = 38). Furthermore, we investigated the relevance between BA metabolism and gastric cancer. There were statistical differences in the metabolism of cholic acid (CA) into deoxycholic acid (DCA) based on the progression of CSG into IM and gastric cancer. Hence, the progression of gastric cancer might be related to the alterations in gut microbiome composition. We provide insight into the etiological mechanisms of the progression of gastric cancer and biomarkers to diagnose and treat gastric cancer.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherPergamon-
dc.relation.isPartOfJOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHBile Acids and Salts / analysis*-
dc.subject.MESHBile Acids and Salts / metabolism-
dc.subject.MESHChromatography, Liquid / methods-
dc.subject.MESHDisease Progression-
dc.subject.MESHGastric Juice / metabolism*-
dc.subject.MESHHistamine / analysis*-
dc.subject.MESHHistamine / metabolism-
dc.subject.MESHHistidine / analysis*-
dc.subject.MESHHistidine / metabolism-
dc.subject.MESHHumans-
dc.subject.MESHMetaplasia / metabolism-
dc.subject.MESHMetaplasia / pathology*-
dc.subject.MESHPrecancerous Conditions / metabolism-
dc.subject.MESHPrecancerous Conditions / pathology*-
dc.subject.MESHStomach Neoplasms / metabolism-
dc.subject.MESHStomach Neoplasms / pathology*-
dc.subject.MESHTandem Mass Spectrometry / methods-
dc.titleAssessing the progression of gastric cancer via profiling of histamine, histidine, and bile acids in gastric juice using LC-MS/MS-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorWonwoong Lee-
dc.contributor.googleauthorJinhee Um-
dc.contributor.googleauthorBoram Hwang-
dc.contributor.googleauthorYong Chan Lee-
dc.contributor.googleauthorBong Chul Chung-
dc.contributor.googleauthorJongki Hong-
dc.identifier.doi10.1016/j.jsbmb.2019.105539-
dc.contributor.localIdA02988-
dc.relation.journalcodeJ01757-
dc.identifier.eissn1879-1220-
dc.identifier.pmid31730800-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0960076019304972-
dc.subject.keywordBile acids-
dc.subject.keywordHistidine decarboxylase-
dc.subject.keywordLC-MS/MS-
dc.subject.keywordGut microbiome-
dc.subject.keywordGastric juice-
dc.subject.keywordGastric cancer-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.affiliatedAuthor이용찬-
dc.citation.volume197-
dc.citation.startPage105539-
dc.identifier.bibliographicCitationJOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, Vol.197 : 105539, 2020-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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