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Survival prediction of liver cancer patients from CT images using deep learning and radiomic feature-based regression

 Hansang Lee  ;  Helen Hong  ;  Jinsil Seong  ;  Jin Sung Kim  ;  Junmo Kim 
 Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol.11314 : 113143L, 2020-03 
Journal Title
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Issue Date
computed tomography ; deep learning ; hepatocellular carcinoma ; radiomics ; survival prediction
Prediction of survival period for patients with hepatocellular carcinoma (HCC) provides important information for treatment planning such as radiotherapy. However, the task is known to be challenging due to the similarity of tumor imaging characteristics from patients with different survival periods. In this paper, we propose a survival prediction method using deep learning and radiomic features from CT images with support vector machine (SVM) regression. First, to extract the deep features, the convolutional neural network (CNN) is trained for the task of classifying the patients for 24-month survival. Second, the radiomic features including texture and shape are extracted from the patient images. After concatenating the radiomic features and the deep features, the SVM regressor is trained to predict the survival period of the patients. The experiment was performed on the CT scans of 171 HCC patients with 5-fold cross validation. In the experiments, the proposed method showed an accuracy of 86.5%, a root-mean-squared-error (RMSE) of 11.6, and a Spearman rank coefficient of 0.11. In comparisons with the deep feature-only- and radiomic feature-only regression results, the proposed method showed improved accuracy and RMSE than both, but lower rank coefficient than the radiomic feature-only regression. It can be observed that (1) the deep learning of CT images has a promising potential for predicting the survival period of HCC patients, and (2) the radiomic feature analysis provides useful information to strengthen the power of deep learning-based survival prediction. © 2020 SPIE.
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1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jinsung(김진성) ORCID logo https://orcid.org/0000-0003-1415-6471
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
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