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Higher cholesterol levels, not statin use, are associated with a lower risk of hepatocellular carcinoma

Authors
 Sang-Wook Yi  ;  Se Hwa Kim  ;  Ki Jun Han  ;  Jee-Jeon Yi  ;  Heechoul Ohrr 
Citation
 BRITISH JOURNAL OF CANCER, Vol.122(5) : 630-633, 2020-03 
Journal Title
BRITISH JOURNAL OF CANCER
ISSN
 0007-0920 
Issue Date
2020-03
MeSH
Carcinoma, Hepatocellular / blood* ; Carcinoma, Hepatocellular / epidemiology* ; Cholesterol / blood* ; Cohort Studies ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage* ; Incidence ; Liver Neoplasms / blood* ; Liver Neoplasms / epidemiology* ; Male ; Proportional Hazards Models ; Republic of Korea / epidemiology
Abstract
We aimed to examine whether statin users have a lower risk of hepatocellular carcinoma (HCC) after careful consideration of prevalent statin use and cholesterol levels. During a mean prospective follow-up of 8.4 years in 400,318 Koreans, 1686 individuals were diagnosed with HCC. When prevalent users were included, HCC risk was reduced by >50% in statin users, regardless of adjustment for total cholesterol (TC). When prevalent users were excluded, new users who initiated statins within 6 months after baseline had a 40% lower risk of HCC (hazard ratio [HR] = 0.59) in a TC-unadjusted analysis. However, this relationship disappeared (HR = 1.16, 95% CI = 0.80-1.69) after adjusting for TC levels measured within 6 months before statin initiation. TC levels had strong inverse associations with HCC in each model. High cholesterol levels at statin initiation, not statin use, were associated with reduced risk of HCC. Our study suggests no protective effect of statins against HCC.
Files in This Item:
T9992020391.pdf Download
DOI
10.1038/s41416-019-0691-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Ohrr, Hee Choul(오희철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190166
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