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응급센터에 내원한 중증외상환자에서 평균혈소판용적의 연속 측정을 통한 다발성 장기부전 예측의 유용성

Other Titles
 Usefulness of serial measurement of the mean platelet volume to predict multiple organ dysfunction syndrome in patients with severe trauma 
Authors
 양현영  ;  정성필  ;  좌민홍  ;  유제성  ;  공태영  ;  고동률  ;  황윤정  ;  이용희  ;  조영준  ;  박인철  ;  김시내 
Citation
 Journal of the Korean Society of Emergency Medicine (대한응급의학회지), Vol.31(2) : 169-180, 2020-04 
Journal Title
Journal of the Korean Society of Emergency Medicine(대한응급의학회지)
ISSN
 1226-4334 
Issue Date
2020-04
Keywords
Trauma ; Multiple organ dysfunction syndrome ; Mean platelet volume ; Prognosis
Abstract
Objective: The early prediction of multiple organ dysfunction syndrome (MODS) in trauma patients and provision of prompt treatment may improve their outcomes. We investigated the efficacy of the mean platelet volume (MPV) for predicting MODS in cases of severe trauma.

Methods: This retrospective, observational cohort study was performed with patients prospectively integrated in a critical pathway of TRAUMA. We analyzed the severe trauma patients admitted to the emergency department (ED), based on the Advanced Trauma Life Support guideline, between January 1, 2011 and May 31, 2017. The outcomes were developed from MODS at least 48 hours after ED admission.

Results: A total of 348 patients were enrolled. An increase in the MPV at 12 hours (odds ratio [OR], 2.611; P<0.001) was a strong independent predictor of MODS development. The increasing predictability of MODS was closely associated with an MPV at 12 hours>8.6 fL (OR, 4.831; P<0.001). The area under the receiver operating characteristic curve (AUROC) value of the MPV at 12 hours (0.751; 95% confidence interval [CI], 0.687-0.818; P<0.01) was not inferior than that of Acute Physiology and Chronic Health Evaluation II score, injury severity score, lactate, and total CO2 for predicting MODS.

Conclusion: MPV was an independent predictor of MODS development in severe trauma patients. Emergency physicians can use the MPV as an ancillary biomarker for predicting MODS.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
Yonsei Authors
Ko, Dong Ryul(고동률) ORCID logo https://orcid.org/0000-0002-3098-2784
Kong, Tae Young(공태영) ORCID logo https://orcid.org/0000-0002-4182-7245
Park, In Cheol(박인철) ORCID logo https://orcid.org/0000-0001-7033-766X
You, Je Sung(유제성) ORCID logo https://orcid.org/0000-0002-2074-6745
Lee, Yong Hee(이용희)
Chung, Sung Phil(정성필) ORCID logo https://orcid.org/0000-0002-3074-011X
Cho, Young Joon(조영준)
Choa, Min Hong(좌민홍) ORCID logo https://orcid.org/0000-0003-0338-994X
Hwang, Yoon Jung(황윤정) ORCID logo https://orcid.org/0000-0001-7286-7699
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190133
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