0 317

Cited 22 times in

Areas of white matter hyperintensities and motor symptoms of Parkinson disease

Authors
 Yoonju Lee  ;  Jeongmin Ko  ;  Ye Eun Choi  ;  Jungsu S Oh  ;  Jae Seung Kim  ;  Mun Kyung Sunwoo  ;  Jung Han Yoon  ;  Suk Yun Kang  ;  Jin Yong Hong 
Citation
 NEUROLOGY, Vol.95(3) : E291-E298, 2020-07 
Journal Title
NEUROLOGY
ISSN
 0028-3878 
Issue Date
2020-07
MeSH
Aged ; Female ; Humans ; Magnetic Resonance Imaging / trends ; Male ; Middle Aged ; Motor Skills Disorders / diagnostic imaging* ; Motor Skills Disorders / metabolism* ; Parkinson Disease / diagnostic imaging* ; Parkinson Disease / metabolism* ; Positron-Emission Tomography / trends ; White Matter / diagnostic imaging* ; White Matter / metabolism*
Abstract
Objective To determine whether deep white matter and periventricular hyperintensities affect the motor symptoms of Parkinson disease (PD) differently, we analyzed MRI and dopamine transporter imaging. Methods We analyzed the medical records of patients with de novo PD who underwent dopamine transporter PET scanning and MRI at their first visit. Deep white matter and periventricular hyperintensities were scored with a visual rating scale, and motor symptoms were assessed by Unified Parkinson's Disease Rating Scale motor score and tremor, rigidity, bradykinesia, and axial symptom subscores. The influence of white matter hyperintensity on motor symptoms was explored using multivariable linear regression models. Results A total of 93 patients (mean age, 67.2 +/- 9.9 years; 44 male) were included and the mean motor score was 25.0 +/- 10.8. Subscores for bradykinesia and axial symptoms were correlated with both deep white matter and periventricular hyperintensities scores. Multivariable linear regression models revealed that deep white matter hyperintensities score was significantly associated with subscore for bradykinesia and periventricular hyperintensities score was associated with subscores for bradykinesia and axial symptoms after adjusting for putaminal dopamine transporter availability and clinical factors. Conclusions These results demonstrate that deep white matter hyperintensities are associated with bradykinesia and periventricular hyperintensities are associated with bradykinesia and axial symptoms in patients with PD independently of the severity of dopaminergic depletion.
Full Text
https://n.neurology.org/content/95/3/e291.long
DOI
10.1212/WNL.0000000000009890
Appears in Collections:
6. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers
Yonsei Authors
Lee, Yoon Ju(이윤주)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190052
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links