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Ablation of Peroxiredoxin V Exacerbates Ischemia/Reperfusion-Induced Kidney Injury in Mice

Authors
 Jiyoung Park  ;  Eun Gyeong Lee  ;  Ho Jin Yi  ;  Nam Hee Kim  ;  Sue Goo Rhee  ;  Hyun Ae Woo 
Citation
 ANTIOXIDANTS, Vol.9(8) : 769, 2020-08 
Journal Title
ANTIOXIDANTS
Issue Date
2020-08
Keywords
peroxiredoxin V ; reactive oxygen species ; renal ischemia ; reperfusion ; renal dysfunction
Abstract
Ischemia/reperfusion (I/R) is one of the major causes of acute kidney injury (AKI) and associated with increased mortality and progression to chronic kidney injury (CKI). Molecular mechanisms underlying I/R injury involve the production and excessive accumulation of reactive oxygen species (ROS). Peroxiredoxin (Prx) V, a cysteine-dependent peroxidase, is located in the cytosol, mitochondria, and peroxisome and has an intensive ROS scavenging activity. Therefore, we focused on the role of Prx V during I/R-induced AKI using Prx V knockout (KO) mice. Ablation of Prx V augmented tubular damage, apoptosis, and declined renal function. Prx V deletion also showed higher susceptibility to I/R injury with increased markers for oxidative stress, ER stress, and inflammation in the kidney. Overall, these results demonstrate that Prx V protects the kidneys against I/R-induced injury.
Files in This Item:
T9992020257.pdf Download
DOI
10.3390/antiox9080769
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Rhee, Sue Goo(이서구)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190035
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