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Ablation of Peroxiredoxin V Exacerbates Ischemia/Reperfusion-Induced Kidney Injury in Mice

DC Field Value Language
dc.contributor.author이서구-
dc.date.accessioned2022-09-02T01:11:11Z-
dc.date.available2022-09-02T01:11:11Z-
dc.date.issued2020-08-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/190035-
dc.description.abstractIschemia/reperfusion (I/R) is one of the major causes of acute kidney injury (AKI) and associated with increased mortality and progression to chronic kidney injury (CKI). Molecular mechanisms underlying I/R injury involve the production and excessive accumulation of reactive oxygen species (ROS). Peroxiredoxin (Prx) V, a cysteine-dependent peroxidase, is located in the cytosol, mitochondria, and peroxisome and has an intensive ROS scavenging activity. Therefore, we focused on the role of Prx V during I/R-induced AKI using Prx V knockout (KO) mice. Ablation of Prx V augmented tubular damage, apoptosis, and declined renal function. Prx V deletion also showed higher susceptibility to I/R injury with increased markers for oxidative stress, ER stress, and inflammation in the kidney. Overall, these results demonstrate that Prx V protects the kidneys against I/R-induced injury.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.relation.isPartOfANTIOXIDANTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAblation of Peroxiredoxin V Exacerbates Ischemia/Reperfusion-Induced Kidney Injury in Mice-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.googleauthorJiyoung Park-
dc.contributor.googleauthorEun Gyeong Lee-
dc.contributor.googleauthorHo Jin Yi-
dc.contributor.googleauthorNam Hee Kim-
dc.contributor.googleauthorSue Goo Rhee-
dc.contributor.googleauthorHyun Ae Woo-
dc.identifier.doi10.3390/antiox9080769-
dc.contributor.localIdA02847-
dc.relation.journalcodeJ03863-
dc.identifier.eissn2076-3921-
dc.identifier.pmid32824836-
dc.subject.keywordperoxiredoxin V-
dc.subject.keywordreactive oxygen species-
dc.subject.keywordrenal ischemia-
dc.subject.keywordreperfusion-
dc.subject.keywordrenal dysfunction-
dc.contributor.alternativeNameRhee, Sue Goo-
dc.contributor.affiliatedAuthor이서구-
dc.citation.volume9-
dc.citation.number8-
dc.citation.startPage769-
dc.identifier.bibliographicCitationANTIOXIDANTS, Vol.9(8) : 769, 2020-08-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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