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Is kidney function associated with primary open-angle glaucoma? Findings from the Asian Eye Epidemiology Consortium

Authors
 Yih-Chung Tham  ;  Yijin Tao  ;  Liang Zhang  ;  Tyler Hyung Taek Rim  ;  Sahil Thakur  ;  Zhi Wei Lim  ;  Miao Li Chee  ;  Mukharram M Bikbov  ;  Gyulli M Kazakbaeva  ;  Ningli Wang  ;  Kai Cao  ;  Jie Hao  ;  Vinay Nangia  ;  Songhomitra Panda-Jonas  ;  Ya Xing Wang  ;  Ian Y Wong  ;  Jonathan Cheuk Hung Chan  ;  Qianli Meng  ;  Charumathi Sabanayagam  ;  Tien Y Wong  ;  Jost B Jonas  ;  Hua Zhong  ;  Ching-Yu Cheng 
Citation
 BRITISH JOURNAL OF OPHTHALMOLOGY, Vol.104(9) : 1298-1303, 2020-09 
Journal Title
BRITISH JOURNAL OF OPHTHALMOLOGY
ISSN
 0007-1161 
Issue Date
2020-09
MeSH
Adult ; Aged ; Asia / epidemiology ; Asians / statistics & numerical data ; Cross-Sectional Studies ; Epidemiologic Studies ; Female ; Glaucoma, Open-Angle / epidemiology ; Glaucoma, Open-Angle / physiopathology* ; Glomerular Filtration Rate ; Humans ; Intraocular Pressure / physiology ; Kidney / physiopathology* ; Male ; Middle Aged ; Renal Insufficiency, Chronic / epidemiology ; Renal Insufficiency, Chronic / physiopathology ; Tonometry, Ocular ; Visual Field Tests ; Visual Fields / physiology
Abstract
Aim To comprehensively examine the association between kidney function and primary open angle glaucoma (POAG) in a large consortium of multiple Asian population-based studies. Methods 28 925 participants (57 340 eyes) from 9 population-based studies (from China, Hong Kong, India, Korea, Russia, Singapore) of the Asian Eye Epidemiology Consortium were included. Across all studies, POAG was defined based on the International Society of Geographical and Epidemiological Ophthalmology criteria. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine. Chronic kidney disease (CKD) was defined as eGFR<60 mL/min/1.73 m(2). Eye-specific data were pooled from each study. Multivariable regression analysis with generalised estimating equation models was performed to evaluate the associations between kidney function with POAG and intraocular pressure (IOP). Results After adjusting for age, gender, study group, hypertension, diabetes, hyperlipidaemia, body mass index, smoking status and IOP, lower eGFR (per 10 mUmin/1.73 m(2) decrease) was not significantly associated with POAG (OR=1.01; p=0.77). Presence of CKD was also not significantly associated with POAG (OR=1.01; p=0.739). Furthermore, lower eGFR and presence of CKD were not associated with IOP (all p >= 0.12), However, in the subgroup of combined Korean and Chinese individuals, significant associations between lower eGFR (OR=1.09; 95% CI 1.00 to 1.18; p=0.048) and severe kidney function decline (<45 mL/min/1.73 m(2); OR=2.57; 95% CI 1.34 to 4.93; p=0.004) with POAG, were observed. Conclusion In this large pooled-analysis of multiple Asian population-based studies, our findings suggest that the association between CKD and POAG may only be present in East Asians specifically but not in the overall Asian population. Further evaluation in Japanese population is warranted to confirm this observation.
Full Text
https://bjo.bmj.com/content/104/9/1298.long
DOI
10.1136/bjophthalmol-2019314890
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Rim, Tyler Hyungtaek(임형택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190011
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