Cited 11 times in
Targeting Autophagy In Disease: Recent Advances In Drug Discovery
DC Field | Value | Language |
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dc.date.accessioned | 2022-09-02T01:08:46Z | - |
dc.date.available | 2022-09-02T01:08:46Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190000 | - |
dc.description.abstract | Introduction Small molecules targeting autophagy have been highly implicated as new therapeutic agents to treat diseases of interest. With the increasing demand for autophagy-targeting drugs, this review attempts to provide an efficient strategy to explore major autophagy-based human disease interventions with newly explored mechanisms using small molecules and promising therapeutic approaches. Areas covered Introduced in this review are direct links and applications among autophagy pathways, their modulators, and phenotypic diseases, along with recent approaches. Autophagy-related diseases, machinery, and compounds are introduced to guide the appropriate investigation of autophagy in the pharmaceutical industry. The authors then provide their expert perspectives on the subject. Expert opinion The self-catabolic intracellular process autophagy occurs in organisms throughout their lifetime, supporting its critical role in organismal health across life stages. Because of the detrimental influence of dysfunctional cells to an organism and their etiology in numerous diseases, maintaining cellular quality control by recycling components through autophagy is essential to prevent health decline. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.relation.isPartOf | Expert Opinion on Drug Discovery | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Autophagy / drug effects* | - |
dc.subject.MESH | Drug Development* | - |
dc.subject.MESH | Drug Discovery* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Molecular Targeted Therapy | - |
dc.title | Targeting Autophagy In Disease: Recent Advances In Drug Discovery | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Dasol Kim | - |
dc.contributor.googleauthor | Hui-Yun Hwang | - |
dc.contributor.googleauthor | Ho Jeong Kwon | - |
dc.identifier.doi | 10.1080/17460441.2020.1773429 | - |
dc.identifier.pmid | 32543957 | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/17460441.2020.1773429 | - |
dc.subject.keyword | Autophagy | - |
dc.subject.keyword | autophagy-related diseases | - |
dc.subject.keyword | autophagy-targeting strategy | - |
dc.subject.keyword | cancer | - |
dc.subject.keyword | proteopathies | - |
dc.subject.keyword | vascular diseases | - |
dc.citation.volume | 15 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1045 | - |
dc.citation.endPage | 1064 | - |
dc.identifier.bibliographicCitation | Expert Opinion on Drug Discovery, Vol.15(9) : 1045-1064, 2020-09 | - |
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