Cited 15 times in
The risk of pregnancy-associated hypertension in women with nonalcoholic fatty liver disease
DC Field | Value | Language |
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dc.contributor.author | 김경민 | - |
dc.date.accessioned | 2022-09-02T01:07:34Z | - |
dc.date.available | 2022-09-02T01:07:34Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189972 | - |
dc.description.abstract | Background & Aims Nonalcoholic fatty liver disease (NAFLD) is an independent predictor of cardiovascular disease (CVD) in non-pregnant adults. Although the biological mechanisms underlying this association are not completely understood, metabolic factors, inflammation, and endothelial dysfunction are likely all involved. The association between NAFLD and pregnancy-associated hypertension (HTN) has not been systematically examined. The aim of this study is to assess the risk of pregnancy-associated HTN in pregnant women with NAFLD. Methods This is secondary analysis of a prospective study of healthy pregnant women. Liver ultrasonography was performed at 10-14 weeks of gestation and maternal blood was taken for the measurement of selenoprotein P (SeP), a hepatokine independently associated with both NAFLD and CVD. Pregnancy-associated HTN was defined as the development of gestational HTN, preeclampsia, or eclampsia. Results Among 877 pregnant women, the risk of developing pregnancy-associated HTN was significantly increased in women with NAFLD compared to those without NAFLD. Grade 2-3 steatosis was a significant predictor of pregnancy-associated HTN, even after adjustment for metabolic risk factors. Circulating levels of SeP were significantly higher in women with versus those without NAFLD (P = .001) and was significantly higher also in women who subsequently developed pregnancy-associated HTN compared with those who did not (P < .005). Conclusions Sonographic evidence of NAFLD at 10-14 weeks is an independent predictor of pregnancy-associated HTN. Circulating levels of SeP at that same gestational age are significantly increased in pregnant women with NAFLD who subsequently develop pregnancy-associated HTN. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | LIVER INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Cardiovascular Diseases* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension* / complications | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease* / complications | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease* / diagnostic imaging | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease* / epidemiology | - |
dc.subject.MESH | Pregnancy | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.title | The risk of pregnancy-associated hypertension in women with nonalcoholic fatty liver disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Young Mi Jung | - |
dc.contributor.googleauthor | Seung Mi Lee | - |
dc.contributor.googleauthor | Subeen Hong | - |
dc.contributor.googleauthor | Ja Nam Koo | - |
dc.contributor.googleauthor | Ig Hwan Oh | - |
dc.contributor.googleauthor | Byoung Jae Kim | - |
dc.contributor.googleauthor | Sun Min Kim | - |
dc.contributor.googleauthor | Sang Youn Kim | - |
dc.contributor.googleauthor | Gyoung Min Kim | - |
dc.contributor.googleauthor | Sae Kyung Joo | - |
dc.contributor.googleauthor | Sue Shin | - |
dc.contributor.googleauthor | Errol R Norwitz | - |
dc.contributor.googleauthor | Chan-Wook Park | - |
dc.contributor.googleauthor | Jong Kwan Jun | - |
dc.contributor.googleauthor | Won Kim | - |
dc.contributor.googleauthor | Joong Shin Park | - |
dc.identifier.doi | 10.1111/liv.14563 | - |
dc.contributor.localId | A00296 | - |
dc.relation.journalcode | J02171 | - |
dc.identifier.eissn | 1478-3231 | - |
dc.identifier.pmid | 32558189 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/liv.14563 | - |
dc.subject.keyword | nonalcoholic fatty liver disease | - |
dc.subject.keyword | pregnancy-associated hypertension | - |
dc.subject.keyword | selenoprotein P | - |
dc.contributor.alternativeName | Kim, Gyoung Min | - |
dc.contributor.affiliatedAuthor | 김경민 | - |
dc.citation.volume | 40 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2417 | - |
dc.citation.endPage | 2426 | - |
dc.identifier.bibliographicCitation | LIVER INTERNATIONAL, Vol.40(10) : 2417-2426, 2020-10 | - |
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