Cited 6 times in
KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1 + stem cells
DC Field | Value | Language |
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dc.contributor.author | 구민희 | - |
dc.contributor.author | 김태일 | - |
dc.contributor.author | 신상준 | - |
dc.contributor.author | 양재문 | - |
dc.date.accessioned | 2022-08-23T00:42:03Z | - |
dc.date.available | 2022-08-23T00:42:03Z | - |
dc.date.issued | 2022-07 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189572 | - |
dc.description.abstract | Redox-active metal ions are pivotal for rapid metabolism, proliferation, and aggression across cancer types, and this presents metal chelation as an attractive cancer cell-targeting strategy. Here, we identify a metal chelator, KS10076, as a potent anti-cancer drug candidate. A metal-bound KS10076 complex with redox potential for generating hydrogen peroxide and superoxide anions induces intracellular reactive oxygen species (ROS). The elevation of ROS by KS10076 promotes the destabilization of signal transducer and activator of transcription 3, removes aldehyde dehydrogenase isoform 1-positive cancer stem cells, and subsequently induces autophagic cell death. Bioinformatic analysis of KS10076 susceptibility in pan-cancer cells shows that KS10076 potentially targets cancer cells with increased mitochondrial function. Furthermore, patient-derived organoid models demonstrate that KS10076 efficiently represses cancer cells with active KRAS, and fluorouracil resistance, which suggests clinical advantages. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.relation.isPartOf | CELL REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aldehyde Dehydrogenase 1 Family | - |
dc.subject.MESH | Apoptosis | - |
dc.subject.MESH | Autophagic Cell Death* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Chelating Agents | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Neoplastic Stem Cells / metabolism | - |
dc.subject.MESH | Oxidation-Reduction | - |
dc.subject.MESH | Reactive Oxygen Species / metabolism | - |
dc.subject.MESH | STAT3 Transcription Factor* / metabolism | - |
dc.subject.MESH | Superoxides / metabolism | - |
dc.title | KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1 + stem cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Jaehee Kim | - |
dc.contributor.googleauthor | Areum Park | - |
dc.contributor.googleauthor | Jieon Hwang | - |
dc.contributor.googleauthor | Xianghua Zhao | - |
dc.contributor.googleauthor | Jaesung Kwak | - |
dc.contributor.googleauthor | Hyun Woo Kim | - |
dc.contributor.googleauthor | Minhee Ku | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Tae Il Kim | - |
dc.contributor.googleauthor | Kyu-Sung Jeong | - |
dc.contributor.googleauthor | Uyeong Choi | - |
dc.contributor.googleauthor | Hyuk Lee | - |
dc.contributor.googleauthor | Sang Joon Shin | - |
dc.identifier.doi | 10.1016/j.celrep.2022.111077 | - |
dc.contributor.localId | A00191 | - |
dc.contributor.localId | A01079 | - |
dc.contributor.localId | A02105 | - |
dc.contributor.localId | A02315 | - |
dc.relation.journalcode | J00488 | - |
dc.identifier.eissn | 2211-1247 | - |
dc.identifier.pmid | 35858554 | - |
dc.subject.keyword | ALDH1+ stem cell elimination | - |
dc.subject.keyword | CP : Cancer | - |
dc.subject.keyword | ROS-induced STAT3 degradation | - |
dc.subject.keyword | autophagic cell death | - |
dc.subject.keyword | metal chelator | - |
dc.subject.keyword | pan-cancer therapeutics | - |
dc.contributor.alternativeName | Ku, Min Hee | - |
dc.contributor.affiliatedAuthor | 구민희 | - |
dc.contributor.affiliatedAuthor | 김태일 | - |
dc.contributor.affiliatedAuthor | 신상준 | - |
dc.contributor.affiliatedAuthor | 양재문 | - |
dc.citation.volume | 40 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 111077 | - |
dc.identifier.bibliographicCitation | CELL REPORTS, Vol.40(3) : 111077, 2022-07 | - |
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