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Metabolic Score for Insulin Resistance Is Inversely Related to Incident Advanced Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease

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dc.contributor.author권유진-
dc.contributor.author이혜선-
dc.date.accessioned2022-08-23T00:39:45Z-
dc.date.available2022-08-23T00:39:45Z-
dc.date.issued2022-07-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/189553-
dc.description.abstractWe determined the relationships between metabolic score for IR (METS-IR), triglyceride-glucose (TyG) index, and homeostatic model assessment for IR (HOMA-IR) and incident advanced liver fibrosis (ALF) and assessed the abilities of the three IR indicators to predict ALF in patients with non-alcoholic fatty liver disease (NAFLD) in adults with NAFLD who were aged 40-69 years old. Among 2218 participants with NAFLD at baseline, the areas under the receiver operating characteristic curve for predicting ALF of the METS-IR was 0.744 (0.679-0.810), significantly higher than that of TyG index (0.644 (0.569-0.720)) or that of HOMA-IR (0.633 (0.556-0.710)). Among 1368 patients with NAFLD and without ALF at baseline, 260 (19.0%) patients with NAFLD progressed to ALF during the 16-year follow-up period. Multivariable Cox proportional hazard regression analysis revealed that the adjusted hazard ratio (95% confidence interval) for incident ALF in the highest tertiles of METS-IR, TyG index, and HOMA-IR compared with the lowest tertile of each IR indicator were 0.5 (0.36-0.91), 0.7 (0.49-1.00), and 1.01 (0.71-1.42), respectively. METS-IR was inversely associated with ALF in patients with NAFLD, which cautiously suggests that the risk of ALF may need to be evaluated when metabolic parameters improve in individuals with NAFLD.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI Publishing-
dc.relation.isPartOfNUTRIENTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHGlucose-
dc.subject.MESHHumans-
dc.subject.MESHInsulin Resistance*-
dc.subject.MESHLiver Cirrhosis / complications-
dc.subject.MESHLiver Cirrhosis / epidemiology-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNon-alcoholic Fatty Liver Disease* / complications-
dc.subject.MESHNon-alcoholic Fatty Liver Disease* / epidemiology-
dc.subject.MESHROC Curve-
dc.subject.MESHTriglycerides-
dc.titleMetabolic Score for Insulin Resistance Is Inversely Related to Incident Advanced Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학교실)-
dc.contributor.googleauthorJun-Hyuk Lee-
dc.contributor.googleauthorYu-Jin Kwon-
dc.contributor.googleauthorKyongmin Park-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorHoon-Ki Park-
dc.contributor.googleauthorJee Hye Han-
dc.contributor.googleauthorSang Bong Ahn-
dc.identifier.doi10.3390/nu14153039-
dc.contributor.localIdA04882-
dc.contributor.localIdA03312-
dc.relation.journalcodeJ02396-
dc.identifier.eissn2072-6643-
dc.identifier.pmid35893894-
dc.subject.keywordKorean-
dc.subject.keywordincidence-
dc.subject.keywordinsulin resistance-
dc.subject.keywordliver fibrosis-
dc.subject.keywordnon-alcoholic fatty liver disease-
dc.contributor.alternativeNameKwon, Yu-Jin-
dc.contributor.affiliatedAuthor권유진-
dc.contributor.affiliatedAuthor이혜선-
dc.citation.volume14-
dc.citation.number15-
dc.citation.startPage3039-
dc.identifier.bibliographicCitationNUTRIENTS, Vol.14(15) : 3039, 2022-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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