Sarcopenia is associated with cardiovascular risk in men with COPD, independent of adiposity

Ah Young Leem; Young Sam Kim; Kung Soo Chung; Moo Suk Park; Young Ae Kang; Young-Mok Park; Ji Ye Jung

doi:10.1186/s12931-022-02109-3

YUHSpace

BROWSE

248 588

Cited 0 times in

Cited 16 times in

Sarcopenia is associated with cardiovascular risk in men with COPD, independent of adiposity

Authors: Ah Young Leem ; Young Sam Kim ; Kung Soo Chung ; Moo Suk Park ; Young Ae Kang ; Young-Mok Park ; Ji Ye Jung

Citation: RESPIRATORY RESEARCH, Vol.23(1) : 185, 2022-07

Journal Title: RESPIRATORY RESEARCH

ISSN: 1465-9921

Issue Date: 2022-07

MeSH: Absorptiometry, Photon ; Adiposity ; Body Mass Index ; Cardiovascular Diseases* / diagnosis ; Cardiovascular Diseases* / epidemiology ; Heart Disease Risk Factors ; Humans ; Male ; Middle Aged ; Nutrition Surveys ; Obesity / diagnosis ; Obesity / epidemiology ; Obesity, Abdominal / diagnosis ; Obesity, Abdominal / epidemiology ; Pulmonary Disease, Chronic Obstructive* / diagnosis ; Pulmonary Disease, Chronic Obstructive* / epidemiology ; Risk Factors ; Sarcopenia* / diagnostic imaging ; Sarcopenia* / epidemiology

Keywords: Adiposity ; Cardiovascular disease ; Chronic obstructive pulmonary disease ; Risk ; Sarcopenia

Abstract: Background: Sarcopenia is a well-established risk factor for atherosclerotic cardiovascular disease (ASCVD), but its relationship with chronic obstructive pulmonary disease (COPD) has not been fully determined. This study is aimed to investigate the association between sarcopenia and risk for ASCVD in patients with COPD, independent of central obesity and fat mass.

Methods: Data regarding 704 men with COPD (mean age: 63.4 years) were extracted from the 2008 to 2011 Korean National Health and Nutrition Examination Surveys. Sarcopenia index and fat mass were assessed using dual-energy X-ray absorptiometry. Sarcopenia was defined according to the presence of sarcopenia index values < 1 standard deviation from the cutoff (0.774) among the study participants. ASCVD risk was evaluated using American College of Cardiology/American Heart Association guidelines. High probability of ASCVD was defined as ASCVD risk > 20%.

Results: The quartile-stratified sarcopenia index was negatively associated with ASCVD risk (P < 0.001). ASCVD risk and prevalence of high ASCVD risk were significantly greater in sarcopenic participants than in non-sarcopenic participants, regardless of central obesity and fat mass (all P < 0.001). Multivariate regression analyses demonstrated an independent association between sarcopenia and ASCVD risk (estimated ± standard error = 3.63 ± 0.77%, P < 0.001) and high ASCVD risk (odds ratio [OR] = 2.32, 95% confidence interval [CI] 1.05-5.15, P = 0.039). Furthermore, sarcopenia was an independent factor for high ASCVD risk in participants with moderate to very severe airflow limitation (OR = 2.97, 95% CI 1.06-8.36, P < 0.001).

Conclusions: Sarcopenia was significantly associated with an increased risk for ASCVD in men with COPD, independent of central obesity and fat mass. High ASCVD risk was significantly associated with sarcopenia, particularly in participants with moderate to very severe airflow limitation.