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Sarcopenia is associated with cardiovascular risk in men with COPD, independent of adiposity

Authors
 Ah Young Leem  ;  Young Sam Kim  ;  Kung Soo Chung  ;  Moo Suk Park  ;  Young Ae Kang  ;  Young-Mok Park  ;  Ji Ye Jung 
Citation
 RESPIRATORY RESEARCH, Vol.23(1) : 185, 2022-07 
Journal Title
RESPIRATORY RESEARCH
ISSN
 1465-9921 
Issue Date
2022-07
MeSH
Absorptiometry, Photon ; Adiposity ; Body Mass Index ; Cardiovascular Diseases* / diagnosis ; Cardiovascular Diseases* / epidemiology ; Heart Disease Risk Factors ; Humans ; Male ; Middle Aged ; Nutrition Surveys ; Obesity / diagnosis ; Obesity / epidemiology ; Obesity, Abdominal / diagnosis ; Obesity, Abdominal / epidemiology ; Pulmonary Disease, Chronic Obstructive* / diagnosis ; Pulmonary Disease, Chronic Obstructive* / epidemiology ; Risk Factors ; Sarcopenia* / diagnostic imaging ; Sarcopenia* / epidemiology
Keywords
Adiposity ; Cardiovascular disease ; Chronic obstructive pulmonary disease ; Risk ; Sarcopenia
Abstract
Background: Sarcopenia is a well-established risk factor for atherosclerotic cardiovascular disease (ASCVD), but its relationship with chronic obstructive pulmonary disease (COPD) has not been fully determined. This study is aimed to investigate the association between sarcopenia and risk for ASCVD in patients with COPD, independent of central obesity and fat mass.

Methods: Data regarding 704 men with COPD (mean age: 63.4 years) were extracted from the 2008 to 2011 Korean National Health and Nutrition Examination Surveys. Sarcopenia index and fat mass were assessed using dual-energy X-ray absorptiometry. Sarcopenia was defined according to the presence of sarcopenia index values < 1 standard deviation from the cutoff (0.774) among the study participants. ASCVD risk was evaluated using American College of Cardiology/American Heart Association guidelines. High probability of ASCVD was defined as ASCVD risk > 20%.

Results: The quartile-stratified sarcopenia index was negatively associated with ASCVD risk (P < 0.001). ASCVD risk and prevalence of high ASCVD risk were significantly greater in sarcopenic participants than in non-sarcopenic participants, regardless of central obesity and fat mass (all P < 0.001). Multivariate regression analyses demonstrated an independent association between sarcopenia and ASCVD risk (estimated ± standard error = 3.63 ± 0.77%, P < 0.001) and high ASCVD risk (odds ratio [OR] = 2.32, 95% confidence interval [CI] 1.05-5.15, P = 0.039). Furthermore, sarcopenia was an independent factor for high ASCVD risk in participants with moderate to very severe airflow limitation (OR = 2.97, 95% CI 1.06-8.36, P < 0.001).

Conclusions: Sarcopenia was significantly associated with an increased risk for ASCVD in men with COPD, independent of central obesity and fat mass. High ASCVD risk was significantly associated with sarcopenia, particularly in participants with moderate to very severe airflow limitation.
Files in This Item:
T202202705.pdf Download
DOI
10.1186/s12931-022-02109-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Park, Youngmok(박영목) ORCID logo https://orcid.org/0000-0002-5669-1491
Leem, Ah Young(임아영) ORCID logo https://orcid.org/0000-0001-5165-3704
Jung, Kyung Soo(정경수) ORCID logo https://orcid.org/0000-0003-1604-8730
Jung, Ji Ye(정지예) ORCID logo https://orcid.org/0000-0003-1589-4142
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/189489
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