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Lesion activity assessment of early caries using dye-enhanced quantitative light-induced fluorescence

 Seok-Woo Park  ;  Si-Mook Kang  ;  Hyung-Suk Lee  ;  Sang-Kyeom Kim  ;  Eun-Song Lee  ;  Bo-Ra Kim  ;  Elbert de Josselin de Jong  ;  Baek-Il Kim 
 SCIENTIFIC REPORTS, Vol.12(1) : 11848, 2022-07 
Journal Title
Issue Date
Animals ; Cattle ; Dental Caries Susceptibility ; Dental Caries* / diagnostic imaging ; Fluorescence ; Fluorescent Dyes ; Quantitative Light-Induced Fluorescence*
We aimed to determine whether dye-enhanced quantitative light-induced fluorescence (DEQLF), wherein porous structure of caries lesions is stained with a fluorescent dye, could quantitatively distinguish between active and inactive caries. A total of 126 bovine specimens were prepared to artificially simulate caries activity. Active caries were demineralized with 1% carbopol solution for 3 (A3), 5 (A5), and 10 days (A10). For inactive caries, half specimens in each group were remineralized with 2% NaF and reallocated into three groups (I3, I5, and I10, respectively). Wet specimens were dried with compressed air for 10 s and then dyed with 100-µM sodium fluorescein for 10 s. Fluorescence images of speicmens were captured with a QLF-digital 2 + Biluminator. Fluorescence intensity (ΔG) was measured in fluorescence images of dyed specimens. ΔG between active and inactive groups was compared using independent t-test, and ΔG among active groups (or inactive groups) were compared using ANOVA (α = 0.05). ΔG in the active groups was 33.7-59.0 higher than that in the inactive groups (P < 0.001). Except between I3 and I5, there was significant differences in ΔG according to the demineralization period (P < 0.001). DEQLF might be used to evaluate early caries activity, and longitudinally monitor changes in lesion activity.
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2. College of Dentistry (치과대학) > Dept. of Preventive Dentistry and Public Oral Health (예방치과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Kang, Si-Mook(강시묵) ORCID logo https://orcid.org/0000-0003-2341-3636
Kim, Baek Il(김백일) ORCID logo https://orcid.org/0000-0001-8234-2327
Kim, Sang-Kyeom(김상겸) ORCID logo https://orcid.org/0000-0002-6380-5039
Lee, Eun Song(이은송) ORCID logo https://orcid.org/0000-0002-2949-4783
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