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Initial Abdominal CT and Laboratory Findings Prior to Diagnosis of Crohn's Disease in Children
DC Field | Value | Language |
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dc.contributor.author | 고홍 | - |
dc.contributor.author | 김승 | - |
dc.contributor.author | 김지수 | - |
dc.contributor.author | 박소원 | - |
dc.contributor.author | 신현주 | - |
dc.contributor.author | 윤혜성 | - |
dc.contributor.author | 이미정 | - |
dc.contributor.author | 한경화 | - |
dc.date.accessioned | 2022-08-23T00:18:29Z | - |
dc.date.available | 2022-08-23T00:18:29Z | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/189363 | - |
dc.description.abstract | Purpose: To identify initial abdominal computed tomography (CT) and laboratory findings prior to a diagnosis of Crohn's disease (CD) in children. Materials and methods: In this retrospective study, patients (≤18 year-old) who were diagnosed with CD from 2004 to 2019 and had abdominal CT just prior to being diagnosed with CD were included in the CD group. Patients (≤18 years old) who were diagnosed with infectious enterocolitis from 2018 to 2019 and had undergone CT prior to being diagnosed with enterocolitis were included as a control group. We assessed the diagnostic performances of initial CT and laboratory findings for the diagnosis of CD using logistic regression and the area under the curve (AUC). Results: In total, 107 patients (50 CD patients, 57 control patients) were included, without an age difference between groups (median 13 years old vs. 11 years old, p=0.119). On univariate logistic regression analysis, multisegmental bowel involvement, mesenteric vessel engorgement, higher portal vein/aorta diameter ratio, longer liver longitudinal diameter, lower hemoglobin (≤12.5 g/dL), lower albumin (≤4 g/dL), and higher platelet (>320×103/µL) levels were significant factors for CD. On multivariate analysis, multisegmental bowel involvement [odds ratio (OR) 111.6, 95% confidence interval (CI) 4.778-2605.925] and lower albumin levels (OR 0.9, 95% CI 0.891-0.993) were significant factors. When these two features were combined, the AUC value was 0.985 with a sensitivity of 96% and specificity of 100% for differentiating CD. Conclusion: Multisegmental bowel involvement on CT and decreased albumin levels can help differentiate CD from infectious enterocolitis in children prior to a definite diagnosis of CD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Albumins | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Crohn Disease* / diagnostic imaging | - |
dc.subject.MESH | Enterocolitis* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Tomography, X-Ray Computed / methods | - |
dc.title | Initial Abdominal CT and Laboratory Findings Prior to Diagnosis of Crohn's Disease in Children | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Choeum Kang | - |
dc.contributor.googleauthor | Haesung Yoon | - |
dc.contributor.googleauthor | Sowon Park | - |
dc.contributor.googleauthor | Jisoo Kim | - |
dc.contributor.googleauthor | Kyunghwa Han | - |
dc.contributor.googleauthor | Seung Kim | - |
dc.contributor.googleauthor | Hong Koh | - |
dc.contributor.googleauthor | Mi-Jung Lee | - |
dc.contributor.googleauthor | Hyun Joo Shin | - |
dc.identifier.doi | 10.3349/ymj.2022.63.7.675 | - |
dc.contributor.localId | A00156 | - |
dc.contributor.localId | A00651 | - |
dc.contributor.localId | A06048 | - |
dc.contributor.localId | A05216 | - |
dc.contributor.localId | A02178 | - |
dc.contributor.localId | A04989 | - |
dc.contributor.localId | A02774 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 35748079 | - |
dc.subject.keyword | Crohn disease | - |
dc.subject.keyword | adolescent | - |
dc.subject.keyword | child | - |
dc.subject.keyword | early diagnosis | - |
dc.subject.keyword | tomography, X-ray computed | - |
dc.contributor.alternativeName | Koh, Hong | - |
dc.contributor.affiliatedAuthor | 고홍 | - |
dc.contributor.affiliatedAuthor | 김승 | - |
dc.contributor.affiliatedAuthor | 김지수 | - |
dc.contributor.affiliatedAuthor | 박소원 | - |
dc.contributor.affiliatedAuthor | 신현주 | - |
dc.contributor.affiliatedAuthor | 윤혜성 | - |
dc.contributor.affiliatedAuthor | 이미정 | - |
dc.citation.volume | 63 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 675 | - |
dc.citation.endPage | 682 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.63(7) : 675-682, 2022-07 | - |
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