235 403

Cited 3 times in

The Extent of Necrosis in Brain Metastases May Predict Subtypes of Primary Cancer and Overall Survival in Patients Receiving Craniotomy

DC Field Value Language
dc.contributor.author박미나-
dc.contributor.author박현호-
dc.contributor.author서상현-
dc.contributor.author안성준-
dc.contributor.author유지환-
dc.contributor.author주비오-
dc.contributor.author차윤진-
dc.date.accessioned2022-08-23T00:15:04Z-
dc.date.available2022-08-23T00:15:04Z-
dc.date.issued2022-03-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/189334-
dc.description.abstractAlthough necrosis is common in brain metastasis (BM), its biological and clinical significances remain unknown. We evaluated necrosis extent differences by primary cancer subtype and correlated BM necrosis to overall survival post-craniotomy. We analyzed 145 BMs of patients receiving craniotomy. Necrosis to tumor ratio (NTR) was measured. Patients were divided into two groups by NTR: BMs with sparse necrosis and with abundant necrosis. Clinical features were compared. To investigate factor relevance for BM necrosis, multivariate logistic regression, random forests, and gradient boosting machine analyses were performed. Kaplan-Meier analysis and log-rank tests were performed to evaluate the effect of BM necrosis on overall survival. Lung cancer was a more common origin for BMs with abundant necrosis (42/72, 58.33%) versus sparse necrosis (23/73, 31.51%, p < 0.01). Primary cancer subtype and tumor volume were the most relevant factors for BM necrosis (p < 0.01). BMs harboring moderately abundant necrosis showed longer survival, versus sparse or highly abundant necrosis (p = 0.04). Lung cancer BM may carry larger necrosis than BMs from other cancers. Further, moderately abundant necrosis in BM may predict a good prognosis post-craniotomy.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfCANCERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleThe Extent of Necrosis in Brain Metastases May Predict Subtypes of Primary Cancer and Overall Survival in Patients Receiving Craniotomy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorJihwan Yoo-
dc.contributor.googleauthorYoon Jin Cha-
dc.contributor.googleauthorHun Ho Park-
dc.contributor.googleauthorMina Park-
dc.contributor.googleauthorBio Joo-
dc.contributor.googleauthorSang Hyun Suh-
dc.contributor.googleauthorSung Jun Ahn-
dc.identifier.doi10.3390/cancers14071694-
dc.contributor.localIdA01460-
dc.contributor.localIdA01750-
dc.contributor.localIdA01886-
dc.contributor.localIdA02237-
dc.contributor.localIdA05158-
dc.contributor.localIdA05842-
dc.contributor.localIdA04001-
dc.relation.journalcodeJ03449-
dc.identifier.eissn2072-6694-
dc.identifier.pmid35406466-
dc.subject.keywordbiomarker-
dc.subject.keywordbrain metastasis-
dc.subject.keywordcraniotomy-
dc.subject.keywordnecrosis-
dc.contributor.alternativeNamePark, Mina-
dc.contributor.affiliatedAuthor박미나-
dc.contributor.affiliatedAuthor박현호-
dc.contributor.affiliatedAuthor서상현-
dc.contributor.affiliatedAuthor안성준-
dc.contributor.affiliatedAuthor유지환-
dc.contributor.affiliatedAuthor주비오-
dc.contributor.affiliatedAuthor차윤진-
dc.citation.volume14-
dc.citation.number7-
dc.citation.startPage1694-
dc.identifier.bibliographicCitationCANCERS, Vol.14(7) : 1694, 2022-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.