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Calcium Supplementation, Risk of Cardiovascular Diseases, and Mortality: A Real-World Study of the Korean National Health Insurance Service Data

 Jae-Min Park  ;  Bora Lee  ;  Young-Sang Kim  ;  Kyung-Won Hong  ;  Yon Chul Park  ;  Dong Hyeok Shin  ;  Yonghwan Kim  ;  Kunhee Han  ;  Kwangyoon Kim  ;  Junghwa Shin  ;  Mina Kim  ;  Bom-Taeck Kim 
 NUTRIENTS, Vol.14(12) : 2538, 2022-06 
Journal Title
Issue Date
Calcium ; Cardiovascular Diseases* / epidemiology ; Cardiovascular Diseases* / etiology ; Dietary Supplements ; Humans ; Ischemic Stroke* ; Myocardial Infarction* / complications ; National Health Programs ; Republic of Korea / epidemiology ; Retrospective Studies ; Risk Factors ; Stroke* / complications
acute myocardial infarction ; calcium supplementation ; cardiovascular diseases ; ischemic stroke ; osteoporosis
Few studies have investigated the effects of calcium supplementation on cardiovascular outcomes in individuals with low calcium intake in real-world settings. This study examined the association between calcium supplementation and cardiovascular outcomes in the Korean population in a real-world setting. This large retrospective cohort study included patients aged ≥45 years first prescribed calcium supplements in 2010. Age- and sex-matched controls were recruited among those who had no prescription for calcium supplements. Longitudinal data were collected on 31 December 2018. Kaplan-Meier estimation and Cox proportional hazard regression analysis were performed. The cumulative incidence of acute myocardial infarction, ischemic stroke, and death was significantly higher in the calcium supplementation group than in the control group (p < 0.05 by log-rank test). The calcium supplementation group had a significantly higher risk of myocardial infarction, ischemic stroke, and death than the control group. Compared to the control group, the hazard ratios (95% confidence intervals) of the incidence of myocardial infarction, stroke, and death in the supplementation group were 1.14 (1.03-1.27), 1.12 (1.05-1.20), and 1.40 (1.32-1.50), respectively, after adjusting for confounding variables. Considering the associated cardiovascular risk, calcium supplementation for osteoporosis treatment should be administered cautiously.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Park, Jae Min(박재민) ORCID logo https://orcid.org/0000-0001-8873-8832
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