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The Role of Proprotein Convertases in Upper Airway Remodeling

Authors
 Sang-Nam Lee  ;  Joo-Heon Yoon 
Citation
 MOLECULES AND CELLS, Vol.45(6) : 353-361, 2022-06 
Journal Title
MOLECULES AND CELLS
ISSN
 1016-8478 
Issue Date
2022-06
MeSH
Airway Remodeling ; Chronic Disease ; Humans ; Hyperplasia / metabolism ; Inflammation / metabolism ; Nasal Mucosa ; Nasal Polyps* ; Proprotein Convertases / metabolism ; Sinusitis*
Keywords
airway remodeling ; chronic rhinosinusitis ; endoproteolytic cleavage ; human nasal epithelial cells ; nasal polyps ; proprotein convertase
Abstract
Chronic rhinosinusitis (CRS) is a multifactorial, heterogeneous disease characterized by persistent inflammation of the sinonasal mucosa and tissue remodeling, which can include basal/progenitor cell hyperplasia, goblet cell hyperplasia, squamous cell metaplasia, loss or dysfunction of ciliated cells, and increased matrix deposition. Repeated injuries can stimulate airway epithelial cells to produce inflammatory mediators that activate epithelial cells, immune cells, or the epithelial-mesenchymal trophic unit. This persistent inflammation can consequently induce aberrant tissue remodeling. However, the molecular mechanisms driving disease within the different molecular CRS subtypes remain inadequately characterized. Numerous secreted and cell surface proteins relevant to airway inflammation and remodeling are initially synthesized as inactive precursor proteins, including growth/differentiation factors and their associated receptors, enzymes, adhesion molecules, neuropeptides, and peptide hormones. Therefore, these precursor proteins require post-translational cleavage by proprotein convertases (PCs) to become fully functional. In this review, we summarize the roles of PCs in CRS-associated tissue remodeling and discuss the therapeutic potential of targeting PCs for CRS treatment.
Files in This Item:
T202202201.pdf Download
DOI
10.14348/molcells.2022.0019
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Yoon, Joo Heon(윤주헌)
Lee, Sang Nam(이상남)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/189308
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