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Vitamin D Deficiency and Neurologic Outcome After Sudden Cardiac Arrest

 Jung-Joon Cha  ;  Jin Wi 
 SHOCK, Vol.52(6) : E146-E152, 2019-12 
Journal Title
Issue Date
Adult ; Aged ; Death, Sudden, Cardiac* ; Disease-Free Survival ; Female ; Humans ; Male ; Middle Aged ; Nervous System Diseases* / blood ; Nervous System Diseases* / etiology ; Nervous System Diseases* / mortality ; Sex Factors ; Survival Rate ; Vitamin D Deficiency* / blood ; Vitamin D Deficiency* / complications ; Vitamin D Deficiency* / mortality
Cerebral performance category ; resuscitation ; sudden cardiac arrest ; vitamin D deficiency
Background: Vitamin D deficiency is related to various cardiovascular diseases, including sudden cardiac arrest (SCA). This study investigated the association of vitamin D level with neurologic outcome and mortality after resuscitation from SCA. Patients and Methods: We enrolled patients who were successfully resuscitated from out-of-hospital cardiac arrest of presumed cardiac cause in Severance Cardiovascular Hospital as a prospective cohort registry. Baseline blood samples including pH, lactate, and vitamin D were obtained without fluid replacement just after hospital admission. Outcome was assessed by cerebral performance category (CPC) score at 1 month after SCA. Favorable outcome was defined as survival with CPC score of 1 or 2, whereas unfavorable one as death or survival with CPC scores of 3 through 5. Severe vitamin D deficiency was defined as 25(OH)D <10 ng/mL. Results: A total of 163 patients were included. Overall 96 (59%) patients had a favorable neurologic outcome, whereas 67 patients (41%) showed unfavorable outcome, including 37 (23%) mortality. Patients with unfavorable outcome were likely to be female and have initial non-shockable rhythm, longer arrest time, severe shock, diabetes, and baseline renal dysfunction. In multivariate analysis, severe vitamin D deficiency was one of the poor prognostic factors of both unfavorable neurologic outcome and mortality after SCA. Conclusions: Vitamin D deficiency is very prevalent and strongly associated with both unfavorable neurologic outcome and mortality in patients resuscitated from SCA.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Wi, Jin(위진) ORCID logo https://orcid.org/0000-0003-0655-5130
Cha, Jung-Joon(차정준) ORCID logo https://orcid.org/0000-0002-8299-1877
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