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Nonalcoholic fatty liver disease is a risk factor for large-for-gestational-age birthweight

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dc.contributor.author김경민-
dc.date.accessioned2022-08-19T06:29:59Z-
dc.date.available2022-08-19T06:29:59Z-
dc.date.issued2019-08-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/189225-
dc.description.abstractObjective Nonalcoholic fatty liver disease (NAFLD) is a well-recognized hepatic manifestation of metabolic disease in adults and has been associated with the development of gestational diabetes (GDM). Hepatic insulin resistance can result in increased release of glucose (from gluconeogenesis) and free fatty acids (due to enhanced lipolysis), which can lead in turn to fetal overgrowth. However, the relationship between maternal metabolic factors (such as circulating levels of triglycerides, free fatty acids [FFA], or adipokines) and excessive fetal birthweight in NAFLD has not been carefully examined. In this study, we evaluated the relationship between NAFLD and the subsequent risk of large-for-gestational-age (LGA) birthweight. Method Singleton nondiabetic pregnant women were evaluated for the presence of fatty liver at 10-14 weeks of gestation by abdominal ultrasound. The degree of fatty liver was classified as Grade 0-3 steatosis. At the time of liver ultrasound, maternal blood was taken after fasting and measured for adiponectin and FFA. LGA was defined as birthweight >90th percentile for gestational age. Results A total of 623 women were included in the analysis. The frequency of LGA was 10.9% (68/623), and the frequency of NAFLD was 18.9%. The risk of LGA increased significantly in patients with Grade 2-3 steatosis in the first trimester. The relationship between Grade 2-3 steatosis and LGA remained significant after adjustment for maternal age, pre-pregnancy BMI, GDM, and maternal serum triglyceride levels. The concentration of maternal blood adiponectin at 10-14 weeks was significantly lower in cases with LGA than non-LGA, but the maternal blood FFA concentrations were not different between the groups. Conclusion The presence of Grade 2-3 steatosis on ultrasound in early pregnancy was associated with the increased risk of delivering an LGA infant, even after adjustment for multiple confounding factors including GDM. Adiponectin may be the linking biomarker between NAFLD and LGA.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHBirth Weight / physiology-
dc.subject.MESHBody Mass Index-
dc.subject.MESHDiabetes, Gestational / epidemiology-
dc.subject.MESHDiabetes, Gestational / physiopathology-
dc.subject.MESHFemale-
dc.subject.MESHFetus-
dc.subject.MESHGestational Age-
dc.subject.MESHHumans-
dc.subject.MESHInfant, Newborn-
dc.subject.MESHInfant, Newborn, Diseases / epidemiology*-
dc.subject.MESHInfant, Newborn, Diseases / physiopathology-
dc.subject.MESHInsulin Resistance / physiology-
dc.subject.MESHNon-alcoholic Fatty Liver Disease / epidemiology*-
dc.subject.MESHNon-alcoholic Fatty Liver Disease / physiopathology-
dc.subject.MESHPregnancy-
dc.subject.MESHPregnancy Complications / epidemiology*-
dc.subject.MESHPregnancy Complications / physiopathology-
dc.subject.MESHRisk Factors-
dc.subject.MESHWeight Gain / physiology-
dc.subject.MESHYoung Adult-
dc.titleNonalcoholic fatty liver disease is a risk factor for large-for-gestational-age birthweight-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorSeung Mi Lee-
dc.contributor.googleauthorByoung Jae Kim-
dc.contributor.googleauthorJa Nam Koo-
dc.contributor.googleauthorErrol R Norwitz-
dc.contributor.googleauthorIg Hwan Oh-
dc.contributor.googleauthorSun Min Kim-
dc.contributor.googleauthorSang Youn Kim-
dc.contributor.googleauthorGyoung Min Kim-
dc.contributor.googleauthorSoo Heon Kwak-
dc.contributor.googleauthorWon Kim-
dc.contributor.googleauthorSae Kyung Joo-
dc.contributor.googleauthorSue Shin-
dc.contributor.googleauthorChanthalakeo Vixa-
dc.contributor.googleauthorChan-Wook Park-
dc.contributor.googleauthorJong Kwan Jun-
dc.contributor.googleauthorJoong Shin Park-
dc.identifier.doi10.1371/journal.pone.0221400-
dc.contributor.localIdA00296-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid31449538-
dc.contributor.alternativeNameKim, Gyoung Min-
dc.contributor.affiliatedAuthor김경민-
dc.citation.volume14-
dc.citation.number8-
dc.citation.startPagee0221400-
dc.identifier.bibliographicCitationPLOS ONE, Vol.14(8) : e0221400, 2019-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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