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Significant changes of the choroid in patients with ocular ischemic syndrome and symptomatic carotid artery stenosis

Authors
 Hae Min Kang  ;  Jeong Hoon Choi  ;  Hyoung Jun Koh  ;  Sung Chul Lee 
Citation
 PLOS ONE, Vol.14(10) : e0224210, 2019-10 
Journal Title
PLOS ONE
Issue Date
2019-10
MeSH
Aged ; Aged, 80 and over ; Carotid Stenosis / complications* ; Choroid Diseases / etiology ; Choroid Diseases / pathology* ; Female ; Humans ; Ischemia / complications* ; Male ; Middle Aged ; Retinal Diseases / complications* ; Retrospective Studies ; Syndrome ; Tomography, Optical Coherence
Abstract
Purpose To evaluated the changes in choroidal vasculature in patients with ocular ischemic syndrome (OIS) and in the ipsilateral eyes of patients with symptomatic carotid artery stenosis (CAS) Method A total of 50 patients (15 patients with OIS, 10 patients with symptomatic CAS, 25 patients of age -and sex-matched control group) were included, and the medical records were retrospectively reviewed. The mean subfoveal choroidal thickness (SFCT) of each eye was measured, and binary images of the choroid were evaluated to compare the mean choroidal area and the luminal area. Results The mean SFCT was 170.5 +/- 75.3 mu m in the eyes with OIS, 154.8 +/- 62.9 mu m in the ipsilateral eyes with symptomatic CAS, and 277.5 +/- 73.2 mu m in the right eyes of the control group patients (P<0.001). The mean choroidal area was 494,478.6 +/- 181,846.2 mu m2 in the eyes with OIS, 453,750.0 +/- 196,725.8 mu m2 in the ipsilateral eyes with symptomatic CAS, and 720,520 +/- 281,319.5 mu m2 in the control group eyes (P = 0.036). The mean luminal area was 333,185.7 +/- 112,665.9 mu m(2) in the eyes with OIS, 313,983.3 +/- 132,032.1 mu m2 in the ipsilateral eyes with symptomatic CAS, and 480,325.0 +/- 185,112.6 mu m2 in the control group eyes (P = 0.046). The mean SFCT, mean choroidal area, and mean luminal area were significantly smaller in the eyes with OIS (P = 0.017, P = 0.005, and P = 0.004, respectively), and those with symptomatic CAS (P = 0.020, P = 0.016, and P = 0.021, respectively) than in the unaffected contralateral eyes. There were no significant differences between the eyes in the control group (P = 0.984, P = 284, and P = 0.413, respectively). Conclusion The mean SFCT, mean choroidal area, and mean luminal area were significantly thinner in the eyes with OIS and the ipsilateral eyes with symptomatic CAS, compared with the control group eyes. The eyes with OIS and those with symptomatic CAS had significantly thinner SFCT, and smaller choroidal area and luminal area than the unaffected contralateral eyes. Choroid may reflect the vascular status of the carotid artery, indicated by choroidal thinning and decreasing choroidal area, especially luminal area.
Files in This Item:
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DOI
10.1371/journal.pone.0224210
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hyoung Jun(고형준) ORCID logo https://orcid.org/0000-0002-5932-8516
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/189224
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