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Association of Body Mass Index with Risk of Major Adverse Cardiovascular Events and Mortality in People with Diabetes

Authors
 Dong Hun Lee  ;  Kyoung Hwa Ha  ;  Hyeon Chang Kim  ;  Dae Jung Kim 
Citation
 JOURNAL OF OBESITY & METABOLIC SYNDROME, Vol.27(1) : 61-70, 2018-03 
Journal Title
JOURNAL OF OBESITY & METABOLIC SYNDROME
ISSN
 2508-6235 
Issue Date
2018-03
Keywords
Body mass index ; Cardiovascular diseases ; Death ; Diabetes mellitus
Abstract
Background: The relationship between cardiovascular and all-cause mortality and obesity in people with diabetes is still controversial. We investigated the association of body mass index (BMI) with the risk of major adverse cardiovascular events (MACE) and all-cause mortality in people with diabetes.

Methods: In total, 48,438 people with diabetes were enrolled in the Korean National Health Insurance Service-National Health Screening Cohort from 2002 to 2003 and were followed until 2013. Baseline BMI was categorized as underweight (<18.5 kg/m2), normal-weight (18.5-22.9 kg/m2), overweight (23.0-24.9 kg/m2), obese class I (25.0-29.9 kg/m2), and obese class II (≥30.0 kg/m2).

Results: During a median of 10.7 years of follow-up (interquartile range, 10.2-11.2 years), there were 7,360 MACE and 5,766 deaths. Compared to those in the normal-weight group, the fully adjusted hazard ratios (HRs) for MACE were 1.09 (95% confidence interval [CI], 0.92-1.29), 0.91 (95% CI, 0.85-0.97), 0.93 (95% CI, 0.88-0.98), and 0.95 (95% CI, 0.84-1.06) for underweight, overweight, obese class I, and obese class II groups, respectively. The HRs for all-cause mortality were 1.75 (95% CI, 1.54-1.99), 0.74 (95% CI, 0.69-0.79), 0.67 (95% CI, 0.63-0.71), and 0.73 (95% CI, 0.63-0.85) for underweight, overweight, obese class I, and obese class II groups, respectively.

Conclusion: In people with diabetes, underweight people had a higher risk for all-cause mortality, whereas overweight or obese people had a lower risk for MACE and all-cause mortality than those with a normal weight.
Files in This Item:
T999201824.pdf Download
DOI
10.7570/jomes.2018.27.1.61
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188938
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