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Perforation in Submucous Cleft Palate Due to Methotrexate-Induced Mucositis in a Patient With Rheumatoid Arthritis

Authors
 Jung Woo Nam 
Citation
 JOURNAL OF CRANIOFACIAL SURGERY, Vol.29(3) : 772-773, 2018-05 
Journal Title
JOURNAL OF CRANIOFACIAL SURGERY
ISSN
 1049-2275 
Issue Date
2018-05
MeSH
Aged ; Antirheumatic Agents / adverse effects* ; Arthritis, Rheumatoid / drug therapy* ; Cleft Palate / diagnostic imaging ; Cleft Palate / pathology* ; Cleft Palate / surgery ; Female ; Humans ; Methotrexate / adverse effects* ; Mouth Mucosa* / diagnostic imaging ; Mucositis / chemically induced* ; Mucositis / complications* ; Mucositis / diagnostic imaging ; Rupture, Spontaneous / diagnostic imaging ; Tomography, X-Ray Computed
Abstract
Spontaneous palatal perforation can be rarely developed by several causes, such as tumor, trauma, and infection. This article reports a patient with large mid-palatal perforation after suffering from severe oral mucositis, which occurred about a month after taking methotrexate (MTX) for rheumatoid arthritis. Through computed tomography and clinical examination, this patient was diagnosed with perforation in unrecognized submucous cleft palate (SMCP) due to drug-induced mucositis. After MTX discontinuation, the oral mucositis was almost healed completely in a month, and the hole was successfully closed by palatoplasty. The author can see that the palatal perforation can occur by oral complication of MTX in SMCP patient. It is an important awareness to dentists as the use of MTX continues to increase for antirheumatic therapy.
Full Text
https://journals.lww.com/jcraniofacialsurgery/Fulltext/2018/05000/Perforation_in_Submucous_Cleft_Palate_Due_to.56.aspx
DOI
10.1097/SCS.0000000000004437
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188931
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