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황반부 부종을 동반한 분지망막정맥폐쇄의 치료에 있어서 유리체강내 베바시주맙의 반응을 예측하는 인자

Other Titles
 Predictive Factors for a Favorable Response to Intravitreal Bevacizumab for Macular Edema Associated with Branch Retinal Vein Occlusion 
Authors
 강현구  ;  서유리  ;  최은영  ;  이성철  ;  김민 
Citation
 Journal of Retina, Vol.3(1) : 20-25, 2018-01 
Journal Title
Journal of Retina
ISSN
 2508-1926 
Issue Date
2018-01
Keywords
Branch retinal vein occlusion ; Intravitreal bevacizumab ; Macular edema ; Prognostic factors
Abstract
Purpose:
To determine the factors for predicting a favorable response to intravitreal bevacizumab (IVB) for macular edema (ME) associated with branch retinal vein occlusion (BRVO).

Methods:
Thirty-seven eyes of patients first diagnosed with BRVO-associated ME and treated with IVB more than twice were included in this retrospective case series. Baseline characteristics, initial best-corrected visual acuity (BCVA), initial central macular thickness (CMT), and change in CMT after 2 consecutive monthly IVB injections were reviewed. Patients were classified into 2 groups according to their IVB response: non-responders were defined as those in whom CMT was not decreased by greater than 10% of the initial value after 2 consecutive monthly injections. The types of observed macular edema were further subdivided into the cystoid macular edema (CME) only, serous retinal detachment (SRD) only, and combined CME and SRD groups for analysis.

Results:
Thirty-three patients were classified as responders and 4 patients were classified as non-responders. The responder group was comprised of significantly older patients than the non-responder group (63.8 ± 11.7 vs. 54.5 ± 1.0, p = 0.034). The initial BCVA of the non-responder group was significantly higher than that of the responder group (logMAR 0.08 ± 1.04 vs. 0.37 ± 0.60, p = 0.003). The anatomical type of ME did not significantly influence the response to IVB. There were no differences in the histories of diabetes mellitus or hypertension between the groups, and the existence of an epiretinal membrane did not appear to affect treatment response.

Conclusions
Patients with better initial BCVA and those who were older appeared to have a more favorable response to IVB treatment in ME due to BRVO.
Files in This Item:
T201806366.pdf Download
DOI
10.21561/jor.2018.3.1.20
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hyun Goo(강현구) ORCID logo https://orcid.org/0000-0001-8359-9618
Kim, Min(김민) ORCID logo https://orcid.org/0000-0003-1873-6959
Seo, Yuri(서유리)
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
Choi, Eun Young(최은영) ORCID logo https://orcid.org/0000-0002-1668-6452
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188871
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