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Inverse association of serum testosterone and sex hormone-binding globulin levels with fatty liver disease in middle-aged and elderly men

Authors
 Yong-Jae Lee 
Citation
 Journal of Korean Institute for Functional Medicine, Vol.5(1) : 1-7, 2022-06 
Journal Title
Journal of Korean Institute for Functional Medicine
Issue Date
2022-06
Keywords
Fatty liver ; Testosterone ; Sex hormone-binding globulin ; Insulin resistance
Abstract
Background: We examined the associations of testosterone and sex hormone-binding globulin (SHBG) levels with fatty liver disease among middle-aged and older men. Methods: This cross-sectional study included 1,121 Korean men aged ≥45 years who participated in a health examination program from 2012 to 2013. Serum testosterone and SHBG levels were divided into quartiles. The odds ratios (ORs) and 95% confidence intervals (95% CIs) for fatty liver disease were calculated according to testosterone and SHBG quartiles with multiple logistic regression analysis. Results: The prevalence of fatty liver disease increased proportionally with decreasing testosterone and SHBG quartiles. In all three models, compared with the fourth quartile, the ORs (95% CIs) of fatty liver disease in the first quartiles were 2.04 (1.33-3.11) for testosterone and 3.30 (2.09-5.20) for SHBG after adjusting confounding factors. Conclusion: Testosterone and SHBG levels were inversely and independently associated with fatty liver disease.
Full Text
https://scholar.kyobobook.co.kr/article/detail/4010028881826
DOI
10.32581/jkifm.2022.5.1.1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188828
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