63 62

Cited 0 times in

New body mass index for predicting prognosis in patients with antineutrophil cytoplasmic antibody-associated vasculitis

Authors
 Jung Y Pyo  ;  Sung S Ahn  ;  Lucy E Lee  ;  Jason J Song  ;  Yong-Beom Park  ;  Sang-Won Lee 
Citation
 JOURNAL OF CLINICAL LABORATORY ANALYSIS, Vol.36(5) : e24357, 2022-05 
Journal Title
JOURNAL OF CLINICAL LABORATORY ANALYSIS
ISSN
 0887-8013 
Issue Date
2022-05
MeSH
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis* / epidemiology ; Antibodies, Antineutrophil Cytoplasmic ; Body Mass Index ; Female ; Humans ; Kidney Failure, Chronic* ; Male ; Prognosis ; Recurrence ; Retrospective Studies ; Thinness / complications ; Thinness / epidemiology
Keywords
antineutrophil cytoplasmic antibody-associated vasculitis ; conventional BMI ; new BMI ; poor outcomes ; underweight
Abstract
Objectives: Body mass index (BMI) is a known indicator of all-cause mortality. However, conventional BMI does not reflect the three-dimensional human body. To overcome this limitation, a new BMI has been proposed that provides a closer approximation of real human body shape. This study investigated the associations between the new BMI and poor outcomes in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV).

Method: We retrospectively reviewed the medical records of 242 patients with AAV in a single tertiary medical center. Based on the new BMI, the patients were categorized into four groups: underweight (<18.5 kg/m2.5 ), healthy weight (18.5 to <25.0 kg/m2.5 ), overweight (25.0 to <30.0 kg/m2.5 ), and obese (≥30.0 kg/m2.5 ). The association among the new BMI and death, relapse, end-stage renal disease (ESRD) development, cerebrovascular accident, and cardiovascular disease was analyzed.

Results: The underweight group, according to the new BMI, had higher hazard ratios (HRs) for all-cause mortality (HR: 3.180, 95% confidence interval [CI]: 1.134-8.922, p = 0.028), relapse (HR: 2.141, 95% CI: 1.019-4.368, p = 0.036), and ESRD development (HR: 2.729, 95% CI: 1.190-6.259, p = 0.018) than the healthy weight group. However, according to the conventional BMI, there were no differences in the risks for all poor outcomes between the underweight and healthy weight groups. Multivariate logistic regression analysis demonstrated that being underweight, according to the new BMI, was an independent risk factor for all-cause mortality (HR: 5.285; 95% CI: 1.468-19.018; p = 0.011).

Conclusion: Being underweight, according to the new BMI, is associated with poor outcomes in patients with AAV.
Files in This Item:
T202201709.pdf Download
DOI
10.1002/jcla.24357
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Beom(박용범)
Song, Jason Jungsik(송정식) ORCID logo https://orcid.org/0000-0003-0662-7704
Ahn, Sung Soo(안성수) ORCID logo https://orcid.org/0000-0002-9002-9880
Lee, Sang-Won(이상원) ORCID logo https://orcid.org/0000-0002-8038-3341
Lee, Lucy Eunju(이은주)
Pyo, Jung Yoon(표정윤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188776
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links