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Heart-Rate-Corrected QT Interval Response to Ramosetron during Robot-Assisted Laparoscopic Prostatectomy: A Randomized Trial

Authors
 Bora Lee  ;  So Yeon Kim  ;  Seung Hyun Kim  ;  Hyukjin Yang  ;  Jeong Hyun Jin  ;  Seung Ho Choi 
Citation
 JOURNAL OF PERSONALIZED MEDICINE, Vol.12(5) : 811, 2022-05 
Journal Title
JOURNAL OF PERSONALIZED MEDICINE
Issue Date
2022-05
Keywords
QTc prolongation ; Trendelenburg ; ramosetron ; robot-assisted laparoscopic radical prostatectomy
Abstract
Ramosetron, often used to prevent postoperative nausea and vomiting, might cause heart-rate-corrected (QTc) interval prolongation, as might robot-assisted laparoscopic prostatectomy (RALP), which requires a steep Trendelenburg position and CO2 pneumoperitoneum. This study aimed to determine how ramosetron administration affects the QTc interval in patients treated with RALP. Fifty-six subjects were randomly assigned to ramosetron (n = 28) or control (n = 28) groups. The ramosetron group received 0.3 mg of ramosetron after anesthetic induction, whereas the control group received normal saline. The QTc interval was measured before and after induction; after 5, 30, and 60 min of being placed in the Trendelenburg position; immediately after being returned to a supine position; and at the end of surgery. Linear mixed models were used to compare QT intervals between groups. QTc intervals did not differ significantly between groups over time (Pgroup×time = 0.111). However, they increased significantly in both groups after placement in the Trendelenburg position compared with before induction (Ptime < 0.001). This increase in QTc continued until the end of surgery in both groups. Based on these findings, ramosetron can be safely administered for the prevention of postoperative nausea and vomiting among patients undergoing RALP.
Files in This Item:
T202201805.pdf Download
DOI
10.3390/jpm12050811
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kim, So Yeon(김소연) ORCID logo https://orcid.org/0000-0001-5352-157X
Kim, Seung Hyun(김승현) ORCID logo https://orcid.org/0000-0003-2127-6324
Lee, Bo Ra(이보라) ORCID logo https://orcid.org/0000-0002-7699-967X
Choi, Seung Ho(최승호) ORCID logo https://orcid.org/0000-0001-8442-4406
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188736
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