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Drug repositioning of polaprezinc for bone fracture healing

Authors
 Eun Ae Ko  ;  Yoo Jung Park  ;  Dong Suk Yoon  ;  Kyoung-Mi Lee  ;  Jihyun Kim  ;  Sujin Jung  ;  Jin Woo Lee  ;  Kwang Hwan Park 
Citation
 COMMUNICATIONS BIOLOGY, Vol.5(1) : 462, 2022-05 
Journal Title
COMMUNICATIONS BIOLOGY
Issue Date
2022-05
MeSH
Animals ; Carnosine* / analogs & derivatives ; Carnosine* / pharmacology ; Drug Repositioning ; Fracture Healing ; Humans ; Mice ; Organometallic Compounds ; Zinc / pharmacology ; Zinc Compounds
Abstract
Fractures and related complications are a common challenge in the field of skeletal tissue engineering. Vitamin D and calcium are the only broadly available medications for fracture healing, while zinc has been recognized as a nutritional supplement for healthy bones. Here, we aimed to use polaprezinc, an anti-ulcer drug and a chelate form of zinc and L-carnosine, as a supplement for fracture healing. Polaprezinc induced upregulation of osteogenesis-related genes and enhanced the osteogenic potential of human bone marrow-derived mesenchymal stem cells and osteoclast differentiation potential of mouse bone marrow-derived monocytes. In mouse experimental models with bone fractures, oral administration of polaprezinc accelerated fracture healing and maintained a high number of both osteoblasts and osteoclasts in the fracture areas. Collectively, polaprezinc promotes the fracture healing process efficiently by enhancing the activity of both osteoblasts and osteoclasts. Therefore, we suggest that drug repositioning of polaprezinc would be helpful for patients with fractures.
Files in This Item:
T202202073.pdf Download
DOI
10.1038/s42003-022-03424-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Kwang Hwan(박광환) ORCID logo https://orcid.org/0000-0002-2110-0559
Park, Yoo Jung(박유정)
Yoon, Dong Suk(윤동석) ORCID logo https://orcid.org/0000-0001-5945-5569
Lee, Kyoung Mi(이경미) ORCID logo https://orcid.org/0000-0002-9038-8162
Lee, Jin Woo(이진우) ORCID logo https://orcid.org/0000-0002-0293-9017
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188621
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