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Glucose and glutamine metabolism-related protein expression in breast ductal carcinoma in situ

Authors
 Hyang Joo Ryu  ;  Ja Seung Koo 
Citation
 NEOPLASMA, Vol.69(3) : 630-639, 2022-05 
Journal Title
NEOPLASMA
ISSN
 0028-2685 
Issue Date
2022-05
MeSH
Biomarkers, Tumor / metabolism ; Breast Neoplasms* ; Carcinoma, Ductal, Breast* / pathology ; Carcinoma, Intraductal, Noninfiltrating* ; Female ; Glucose ; Glutamine ; Humans ; Large Neutral Amino Acid-Transporter 1 ; Receptor, ErbB-2 / metabolism ; Triple Negative Breast Neoplasms* / pathology
Abstract
Glucose and glutamine metabolism is involved in important tumor mechanisms. Metabolism-related protein expression has been previously reported to predict tumor prognosis. We aimed to investigate glucose and glutamine metabolism-related protein expression and its implication in breast ductal carcinoma in situ (DCIS). A tissue microarray was prepared for 205 DCIS cases. Glucose and glutamine metabolism-related proteins were immunostained. Based on the results of estrogen receptor, progesterone receptor, human epidermal growth factor receptor (HER)-2, and Ki-67, DCIS was classified into the luminal type, HER-2 type, and triple-negative breast cancer (TNBC). DCIS stroma was classified into non-inflammatory and inflammatory types per stromal histology. DCIS (N=205) was classified into luminal type (n=112), HER-2 type (n=81), and TNBC (n=12). Hexokinase II (p=0.044), GLS (p=0.003), and SLC7A5 (p<0.001) expression rates were the highest in TNBC. Inflammatory type stroma showed higher SLC7A5 (p<0.001) and SLC7A11 (p=0.008) expression rates than non-inflammatory type stroma. In summary, DCIS demonstrated differential expression of metabolism-related proteins according to the molecular subtype and stromal features. TNBC showed the highest glucose and glutamine metabolism-related protein expression, and inflammatory type stroma showed higher glutamine metabolism-related protein expression than non-inflammatory type stroma.
Full Text
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DOI
10.4149/neo_2022_220103N3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Ryu, Hyang-Joo(류향주)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188619
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