Cited 2 times in
Glucose and glutamine metabolism-related protein expression in breast ductal carcinoma in situ
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 류향주 | - |
dc.date.accessioned | 2022-07-08T03:00:38Z | - |
dc.date.available | 2022-07-08T03:00:38Z | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 0028-2685 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188619 | - |
dc.description.abstract | Glucose and glutamine metabolism is involved in important tumor mechanisms. Metabolism-related protein expression has been previously reported to predict tumor prognosis. We aimed to investigate glucose and glutamine metabolism-related protein expression and its implication in breast ductal carcinoma in situ (DCIS). A tissue microarray was prepared for 205 DCIS cases. Glucose and glutamine metabolism-related proteins were immunostained. Based on the results of estrogen receptor, progesterone receptor, human epidermal growth factor receptor (HER)-2, and Ki-67, DCIS was classified into the luminal type, HER-2 type, and triple-negative breast cancer (TNBC). DCIS stroma was classified into non-inflammatory and inflammatory types per stromal histology. DCIS (N=205) was classified into luminal type (n=112), HER-2 type (n=81), and TNBC (n=12). Hexokinase II (p=0.044), GLS (p=0.003), and SLC7A5 (p<0.001) expression rates were the highest in TNBC. Inflammatory type stroma showed higher SLC7A5 (p<0.001) and SLC7A11 (p=0.008) expression rates than non-inflammatory type stroma. In summary, DCIS demonstrated differential expression of metabolism-related proteins according to the molecular subtype and stromal features. TNBC showed the highest glucose and glutamine metabolism-related protein expression, and inflammatory type stroma showed higher glutamine metabolism-related protein expression than non-inflammatory type stroma. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | AE Press | - |
dc.relation.isPartOf | NEOPLASMA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Biomarkers, Tumor / metabolism | - |
dc.subject.MESH | Breast Neoplasms* | - |
dc.subject.MESH | Carcinoma, Ductal, Breast* / pathology | - |
dc.subject.MESH | Carcinoma, Intraductal, Noninfiltrating* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glucose | - |
dc.subject.MESH | Glutamine | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Large Neutral Amino Acid-Transporter 1 | - |
dc.subject.MESH | Receptor, ErbB-2 / metabolism | - |
dc.subject.MESH | Triple Negative Breast Neoplasms* / pathology | - |
dc.title | Glucose and glutamine metabolism-related protein expression in breast ductal carcinoma in situ | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Hyang Joo Ryu | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.4149/neo_2022_220103N3 | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A06168 | - |
dc.relation.journalcode | J02313 | - |
dc.identifier.eissn | 1338-4317 | - |
dc.identifier.pmid | 35263998 | - |
dc.identifier.url | http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7600&category_id=180&option=com_virtuemart&vmcchk=1&Itemid=1 | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.contributor.affiliatedAuthor | 류향주 | - |
dc.citation.volume | 69 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 630 | - |
dc.citation.endPage | 639 | - |
dc.identifier.bibliographicCitation | NEOPLASMA, Vol.69(3) : 630-639, 2022-05 | - |
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