14 30

Cited 0 times in

Interictal plasma glutamate levels are elevated in individuals with episodic and chronic migraine

Authors
 Chae Gyu Park  ;  Min Kyung Chu 
Citation
 SCIENTIFIC REPORTS, Vol.12(1) : 6921, 2022-04 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2022-04
MeSH
Central Nervous System Sensitization ; Female ; Glutamic Acid* ; Headache ; Humans ; Migraine Disorders* ; Pain
Abstract
Glutamate is implicated in migraine pathogenesis including central sensitization and pain transmission. Altered plasma glutamate levels has been noted in migraine. Chronic migraine (CM) presented a higher degree of central sensitization and pain transmission than episodic migraine (EM). However, no study has evaluated plasma glutamate levels separately in EM and CM. This study aimed to assess plasma glutamate levels in EM and CM compared to controls. An enzyme-linked immunosorbent assay was used to assess plasma glutamate levels in females with EM (n = 98) and CM (n = 92) as well as controls (n = 50). Plasma glutamate levels in participants with EM (median and interquartile range, 49.73 [40.82-66.12] μmol/L, p < 0.001) and CM (58.70 [44.64-72.46] μmol/L, p < 0.001) were significantly higher than those in controls (38.79 [29.50-53.60] μmol/L). Glutamate levels were not significantly different between participants with EM and CM (p = 0.075). There was no significant association of plasma glutamate levels with headache frequency (exponential and 95% confidence interval, 1.285 [0.941-1.755]) and intensity (mild, 59.95 [59.95-59.95] μmol/L vs. moderate, 52.76 [40.83-106.89] μmol/L vs. severe, 55.16 [42.34-68.03] μmol/L, p = 0.472). The plasma glutamate level is a potential indicator for EM and CM.
Files in This Item:
T202201510.pdf Download
DOI
10.1038/s41598-022-10883-9
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Park, Chae Gyu(박채규) ORCID logo https://orcid.org/0000-0003-1906-1308
Chu, Min Kyung(주민경) ORCID logo https://orcid.org/0000-0001-6221-1346
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188577
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links