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Ideal cardiovascular health duration and risk of chronic kidney disease and cardiovascular disease

Authors
 So Mi Jemma Cho  ;  Justin Y Jeon  ;  Tae-Hyun Yoo  ;  Hae-Young Lee  ;  Yong-Ho Lee  ;  Hyeon Chang Kim 
Citation
 HEART, Vol.108(7) : 523-528, 2022-04 
Journal Title
HEART
ISSN
 1355-6037 
Issue Date
2022-04
MeSH
Cardiovascular Diseases* / diagnosis ; Cardiovascular Diseases* / epidemiology ; Cardiovascular Diseases* / etiology ; Cardiovascular System* ; Female ; Health Status ; Humans ; Male ; Middle Aged ; Renal Insufficiency, Chronic* / diagnosis ; Renal Insufficiency, Chronic* / epidemiology ; Risk Factors
Keywords
epidemiology ; risk factors
Abstract
Objective: Increasing number of clinical guidelines are adopting comprehensive cardiovascular risk assessment tools for treatment decision and disease management. Yet, little is known regarding cardiovascular risks associated with the length of favourable cardiometabolic profile. In this context, we examined whether the duration of strictly ideal cardiovascular health (CVH), based on body mass index, blood pressure, fasting glucose, total cholesterol, cigarette smoking, alcohol drinking and physical activity, in middle age is associated with risk of developing chronic kidney disease (CKD) and cardiovascular disease (CVD) in mid-to-late life.

Methods: From the Korean Genome and Epidemiology Study Ansung-Ansan cohort, we included 8020 participants (median age 50.0 years, 47.9% male), of whom, 7854 without CKD and 7796 without CVD at baseline. Cox proportional hazards models were employed to assess CKD and CVD risks, adjusting for age, sex, education level, examination sites and renal markers.

Results: Over a median follow-up of 15.0 years, 1401 cases of CKD and 493 cases of CVD were newly developed. Compared with participants with <5 years of ideal CVH duration, HR (95% CI) of those who maintained for 5-<10 years or ≥10 years had negatively graded risks for CKD (5-<10 years, 0.63 (0.39 to 0.93); ≥10 years, 0.33 (0.15 to 0.74)) and CVD (5-<10 years, 0.83 (0.54 to 1.27); ≥10 years, 0.22 (0.08 to 0.60)). In parallel, participants with delayed decline to suboptimal level had lower disease risks compared with counterparts with consistently suboptimal CVH.

Conclusion: Our findings confer that maintaining favourable health behaviours and clinical risk factor levels in midlife will improve later-life cardiovascular outcomes.
Full Text
https://heart.bmj.com/content/108/7/523.long
DOI
10.1136/heartjnl-2021-320180
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188574
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