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Nanotheranostics of Pre-Stenotic Vessels By Target Touch-On Signaling of Peptide Navigator

Authors
 Seung Eun Yu  ;  Seyong Chung  ;  Hyun-Su Ha  ;  Dae-Hyun Kim  ;  Sewoom Baek  ;  Tae Young Kim  ;  Songhyun Lee  ;  Hyo-Jin Yoon  ;  Soon Won Chung  ;  Jung Bok Lee  ;  Young Min Shin  ;  Hye-Seon Kim  ;  Si Young Kim  ;  Joon-Sang Park  ;  Chang-Soo Kim  ;  Hak-Joon Sung 
Citation
 ADVANCED FUNCTIONAL MATERIALS, Vol.32(15) : 2110368, 2022-04 
Journal Title
ADVANCED FUNCTIONAL MATERIALS
ISSN
 1616-301X 
Issue Date
2022-04
Abstract
Navigation of nanoparticles to target sites of blood flow disturbance markedly upgrades the diagnostic paradigm in vascular medicine. The theranostic treatment of pre-stenotic vessels can prevent the irreversible occlusion process effectively. Here, these nanotheranostic functions are established by displaying CDK9(cyclin-dependent kinase 9)-targeting peptide (P.) onto nanovesicles (NV) and liposomes using the navigation function and subsequent binding-on signaling of P. as a game-changer. When rabbit vessels are allografted with injecting contrast-loaded P. liposomes, the case-dependent stenotic degree after 2–6 weeks can be diagnosed accurately within 2–4 days via computed tomography imaging with cross-validation in a mouse model of partial carotid ligation. Furthermore, the anti-CDK9 signaling of P. NV is activated post-targeting and effectively prevents vascular stenosis by suppressing inflammation and lipotoxicity in the vessels, serum, and/or liver. CDK9 targeting is confirmed using computer, in vitro, and in vivo models. This study demonstrates an unprecedented nanotheranostic function for future clinical applications.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202110368
DOI
10.1002/adfm.202110368
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Sung, Hak-Joon(성학준) ORCID logo https://orcid.org/0000-0003-2312-2484
Shin, Young Min(신영민)
Yoon, Hyo-Jin(윤효진)
Chung, Seyong(정세용)
Ha, Hyun-Su(하현수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188561
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