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Effectiveness of Atomoxetine (Strattera) for the Treatment of Poststroke Aphasia Combined With Cognitive Impairment

Authors
 Jong Mi Park  ;  Soojin Choi  ;  Yong Wook Kim 
Citation
 CLINICAL NEUROPHARMACOLOGY, Vol.45(2) : 17-20, 2022-03 
Journal Title
CLINICAL NEUROPHARMACOLOGY
ISSN
 0362-5664 
Issue Date
2022-03
MeSH
Aphasia* / drug therapy ; Aphasia* / etiology ; Aphasia* / rehabilitation ; Atomoxetine Hydrochloride / therapeutic use ; Cognitive Dysfunction* / drug therapy ; Cognitive Dysfunction* / etiology ; Humans ; Mental Status and Dementia Tests ; Stroke* / complications
Abstract
Objective: In this study, we aimed for the first time to evaluate the effectiveness of atomoxetine (Strattera) in the treatment of cognitive impairment and aphasia after stroke in a large sample.

Methods: We reviewed the data of 106 patients with poststroke aphasia and cognitive impairment (atomoxetine treatment group = 55 patients vs control group = 51 patients), including scores of the Korean version of the Mini-Mental State Examination (K-MMSE) and the Korean version of the Western Aphasia Battery. Wilcoxon signed-rank tests were used to compare the initial and follow-up K-MMSE and Korean version of the Western Aphasia Battery scores. Mann-Whitney U tests were used to compare the degree of improvement in K-MMSE and Aphasia Quotient (AQ) scores between the atomoxetine and control groups.

Results: Baseline characteristics including age, years of education, and scores of the initial Functional Independence Measure, Korean version of the Modified Barthel Index, Hamilton Depression Rating Scale, K-MMSE, and AQ did not differ significantly between the 2 groups. Follow-up K-MMSE and AQ scores were significantly better than the initial scores in both the treatment and control groups. However, improvements in K-MMSE scores were significantly greater in the treatment group than in the control group. In addition, the atomoxetine group had significantly higher AQ scores than the control group, especially for auditory verbal comprehension and naming.

Conclusions: Atomoxetine has been shown to significantly improve cognitive function and language in patients with poststroke aphasia. It is also the first study to report improvement in auditory comprehension and naming by administration of atomoxetine.
Full Text
https://journals.lww.com/clinicalneuropharm/Fulltext/2022/03000/Effectiveness_of_Atomoxetine__Strattera__for_the.1.aspx
DOI
10.1097/WNF.0000000000000495
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yong Wook(김용욱) ORCID logo https://orcid.org/0000-0002-5234-2454
Park, Jong Mi(박종미)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188422
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