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Long-term survival after CCRT and HAIC followed by ALPPS for hepatocellular carcinoma with portal vein invasion: a case report

Authors
 In-Jung Kim  ;  Sung Hwan Yoo  ;  Jung Il Lee  ;  Kwan Sik Lee  ;  Hyun Woong Lee  ;  Jin Hong Lim 
Citation
 Journal of Liver Cancer (대한간암학회지), Vol.22(1) : 84-90, 2022-03 
Journal Title
Journal of Liver Cancer(대한간암학회지)
ISSN
 2288-8128 
Issue Date
2022-03
Keywords
Carcinoma ; hepatocellular ; Portal vein ; Hepatectomy ; Concurrent chemoradiotherapy ; Case reports
Abstract
There are various methods for treating advanced hepatocellular carcinoma with portal vein invasion, such as systemic chemotherapy, transarterial chemoembolization, transarterial radioembolization, and concurrent chemoradiotherapy. These methods have similar clinical efficacy but are designed with a palliative aim. Herein, we report a case that experienced complete remission through “associating liver partition and portal vein ligation for staged hepatectomy (ALPPS)” after concurrent chemoradiotherapy and hepatic artery infusion chemotherapy. In this patient, concurrent chemoradiotherapy and hepatic artery infusion chemotherapy induced substantial tumor shrinkage, and hypertrophy of the nontumor liver was sufficiently induced by portal vein ligation (stage 1 surgery) followed by curative resection (stage 2 surgery). Using this approach, long-term survival with no evidence of recurrence was achieved at 16 months. Therefore, the optimal use of ALPPS requires sufficient consideration in cases of significant hepatocellular carcinoma shrinkage for curative purposes.
Files in This Item:
T202201061.pdf Download
DOI
10.17998/jlc.2022.03.07
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Yoo, Sung Hwan(유성환)
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
Lee, Jung Il(이정일) ORCID logo https://orcid.org/0000-0002-0142-1398
Lee, Hyun Woong(이현웅) ORCID logo https://orcid.org/0000-0002-6958-3035
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188398
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