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Clinical and Microbiological Risk Factors for Severe Clostridioides difficile Infections

Other Titles
 중증 Clostridioides difficile 감염의 임상 및 미생물학적 위험인자 
 Young Ah Kim  ;  Heejung Kim  ;  Dokyun Kim  ;  Changseung Liu  ;  Seok Hoon Jeong 
 Annals of Clinical Microbiology, Vol.25(1) : 21-28, 2022-03 
Journal Title
Annals of Clinical Microbiology
Issue Date
Clostridioides difficile ; Risk factor ; Severe infection
Background: There has been a marked increase in the mortality rate associated with
Clostridioides difficile infection (CDI) globally since 2003, with the emergence of binary toxin producing ribotype 027 strains. However, the molecular epidemiology of C. difficile shows
regional differences and ribotype 027 is not common in Korea. In this study, the risk factors
for severe CDI were evaluated, while considering the region-specific molecular epidemiology.
Methods: A retrospective case-control study was performed. Cases (n = 149) included patients
with severe CDI or severe complicated CDI. Controls (n = 155) consisted of patients with non severe CDI.
Results: Advanced age (odds ratio [OR] = 1.017, P = 0.0358), a history of chemotherapy (OR =
2.695, P = 0.0464), and ribotype 002 (OR = 3.406, P = 0.0231) were statistically significant factors
associated with severe CDI in a multivariate analysis.
Conclusion: Ribotype 002 was found to be a significant risk factor for severe CDI in this study.
Therefore, the surveillance of C. difficile ribotypes is recommended to monitor the spread of
high-risk clones
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dokyun(김도균) ORCID logo https://orcid.org/0000-0002-0348-5440
Kim, Heejung(김희정) ORCID logo https://orcid.org/0000-0002-0190-703X
Liu, Changseung(유창승) ORCID logo https://orcid.org/0000-0002-8777-7431
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
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