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Clinical and Microbiological Risk Factors for Severe Clostridioides difficile Infections
DC Field | Value | Language |
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dc.contributor.author | 김도균 | - |
dc.contributor.author | 김희정 | - |
dc.contributor.author | 유창승 | - |
dc.contributor.author | 정석훈 | - |
dc.date.accessioned | 2022-05-09T17:04:53Z | - |
dc.date.available | 2022-05-09T17:04:53Z | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 2288-0585 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188368 | - |
dc.description.abstract | Background: There has been a marked increase in the mortality rate associated with Clostridioides difficile infection (CDI) globally since 2003, with the emergence of binary toxin producing ribotype 027 strains. However, the molecular epidemiology of C. difficile shows regional differences and ribotype 027 is not common in Korea. In this study, the risk factors for severe CDI were evaluated, while considering the region-specific molecular epidemiology. Methods: A retrospective case-control study was performed. Cases (n = 149) included patients with severe CDI or severe complicated CDI. Controls (n = 155) consisted of patients with non severe CDI. Results: Advanced age (odds ratio [OR] = 1.017, P = 0.0358), a history of chemotherapy (OR = 2.695, P = 0.0464), and ribotype 002 (OR = 3.406, P = 0.0231) were statistically significant factors associated with severe CDI in a multivariate analysis. Conclusion: Ribotype 002 was found to be a significant risk factor for severe CDI in this study. Therefore, the surveillance of C. difficile ribotypes is recommended to monitor the spread of high-risk clones | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society of Clinical Microbiology | - |
dc.relation.isPartOf | Annals of Clinical Microbiology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Clinical and Microbiological Risk Factors for Severe Clostridioides difficile Infections | - |
dc.title.alternative | 중증 Clostridioides difficile 감염의 임상 및 미생물학적 위험인자 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Young Ah Kim | - |
dc.contributor.googleauthor | Heejung Kim | - |
dc.contributor.googleauthor | Dokyun Kim | - |
dc.contributor.googleauthor | Changseung Liu | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.identifier.doi | 10.5145/ACM.2022.25.1.3 | - |
dc.contributor.localId | A04891 | - |
dc.contributor.localId | A01219 | - |
dc.contributor.localId | A05704 | - |
dc.contributor.localId | A03619 | - |
dc.relation.journalcode | J00156 | - |
dc.identifier.eissn | 2288-6850 | - |
dc.subject.keyword | Clostridioides difficile | - |
dc.subject.keyword | Risk factor | - |
dc.subject.keyword | Severe infection | - |
dc.contributor.alternativeName | Kim, Dokyun | - |
dc.contributor.affiliatedAuthor | 김도균 | - |
dc.contributor.affiliatedAuthor | 김희정 | - |
dc.contributor.affiliatedAuthor | 유창승 | - |
dc.contributor.affiliatedAuthor | 정석훈 | - |
dc.citation.volume | 25 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 21 | - |
dc.citation.endPage | 28 | - |
dc.identifier.bibliographicCitation | Annals of Clinical Microbiology, Vol.25(1) : 21-28, 2022-03 | - |
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