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Effect of the Number of Micro-Osteoperforations on the Rate of Tooth Movement and Periodontal Response in Mice

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dc.contributor.author이동준-
dc.contributor.author정한성-
dc.contributor.author차정열-
dc.contributor.author최윤정-
dc.contributor.author황충주-
dc.contributor.author김은정-
dc.date.accessioned2022-05-09T17:04:40Z-
dc.date.available2022-05-09T17:04:40Z-
dc.date.issued2022-03-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188366-
dc.description.abstractAccelerated tooth movement can be achieved using micro-osteoperforations (MOPs) to stimulate regeneration of the alveolar bone during minimally invasive surgical trauma. However, there is currently no standardized protocol and limited reports regarding the side effects of MOPs based on biological evidence. This study sought to evaluate the biological effects of the number of MOPs on orthodontic tooth movement (OTM) and the potential risk for root resorption. Male CD1 mice were divided into 4 groups based on the number of MOPs, as follows: Sham; 0MOP+OTM; 2MOP+OTM; and 4MOP+OTM groups. Tooth movement distance and the number of osteoclasts were higher whereas bone volume and trabecular number were lower in the 4MOP+OTM group compared to those of the 0MOP+OTM group. Immunofluorescent assay analysis indicated that the 4MOP+OTM group was positively associated with rapid cementum regeneration and periodontal ligament tissue formation. Our findings revealed that the MOP procedure affected tooth movement and did not significantly contribute to root resorption, whereas it may promote constitutive activation of cementogenesis.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFRONTIERS IN PHYSIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEffect of the Number of Micro-Osteoperforations on the Rate of Tooth Movement and Periodontal Response in Mice-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentOthers-
dc.contributor.googleauthorTselmuun Erdenebat-
dc.contributor.googleauthorDong-Joon Lee-
dc.contributor.googleauthorSu-Jung Kim-
dc.contributor.googleauthorYoon Jeong Choi-
dc.contributor.googleauthorEun-Jung Kim-
dc.contributor.googleauthorEun-Hack Choi-
dc.contributor.googleauthorJing Liu-
dc.contributor.googleauthorChung-Ju Hwang-
dc.contributor.googleauthorHan-Sung Jung-
dc.contributor.googleauthorJung-Yul Cha-
dc.identifier.doi10.3389/fphys.2022.837094-
dc.contributor.localIdA02732-
dc.contributor.localIdA03758-
dc.contributor.localIdA04006-
dc.contributor.localIdA04139-
dc.contributor.localIdA04492-
dc.relation.journalcodeJ02868-
dc.identifier.eissn1664-042X-
dc.identifier.pmid35309083-
dc.subject.keywordbone formation-
dc.subject.keywordcementum-
dc.subject.keywordmicro-CT-
dc.subject.keywordmicro-osteoperforation-
dc.subject.keywordorthodontic tooth movement-
dc.subject.keywordroot resorption-
dc.contributor.alternativeNameLee, Dong Joon-
dc.contributor.affiliatedAuthor이동준-
dc.contributor.affiliatedAuthor정한성-
dc.contributor.affiliatedAuthor차정열-
dc.contributor.affiliatedAuthor최윤정-
dc.contributor.affiliatedAuthor황충주-
dc.citation.volume13-
dc.citation.startPage837094-
dc.identifier.bibliographicCitationFRONTIERS IN PHYSIOLOGY, Vol.13 : 837094, 2022-03-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers

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