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Effects of intraoperative dexmedetomidine infusion on renal function in elective living donor kidney transplantation: a randomized controlled trial

Authors
 Jin Ha Park  ;  Bon-Nyeo Koo  ;  Min-Soo Kim  ;  Dongkwan Shin  ;  Young-Lan Kwak 
Citation
 CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE, Vol.69(4) : 448-459, 2022-04 
Journal Title
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
ISSN
 0832-610X 
Issue Date
2022-04
MeSH
Dexmedetomidine* / pharmacology ; Glomerular Filtration Rate ; Humans ; Kidney / physiology ; Kidney Transplantation* ; Living Donors
Keywords
biomarkers ; delayed graft function ; dexmedetomidine ; kidney transplantation ; renal function
Abstract
Purpose: Ischemia-reperfusion injury is inevitable during donor organ harvest and recipient allograft reperfusion in kidney transplantation, and affects graft outcomes. Dexmedetomidine, an α2-adrenoreceptor agonist, has renoprotective effects against ischemia-reperfusion injury. We investigated the effects of intraoperative dexmedetomidine infusion on renal function and the development of delayed graft function after elective living donor kidney transplantation in a randomized controlled trial.

Methods: A total of 104 patients were randomly assigned to receive either an intraoperative infusion of dexmedetomidine 0.4 μg·kg-1·hr-1 or 0.9% saline. The primary outcome was the serum creatinine level on postoperative day (POD) 7. Secondary outcomes were renal function and the degree of inflammation and included the following variables: serum creatinine level and estimated glomerular filtration rate up to six months; incidence of delayed graft function; and levels of serum cystatin C, plasma interleukin (IL)-1β, and IL-18 during the perioperative period.

Results: The mean (standard deviation) serum creatinine level on POD 7 was comparable between the groups (dexmedetomidine vs control: 1.11 [0.87] mg·dL-1 vs 1.06 [0.73] mg·dL-1; mean difference, 0.05; 95% confidence interval, -0.27 to 0.36; P = 0.77). Delayed graft function occurred in one patient in each group (odds ratio, 1.020; P > 0.99). There were no significant differences in the secondary outcomes between the groups (all P > 0.05).

Conclusions: Intraoperative dexmedetomidine infusion did not produce any beneficial effects on renal function or delayed graft function in patients undergoing elective living donor kidney transplantation.

Study registration: www.

Clinicaltrials: gov (NCT03327389); registered 31 October 2017.
Full Text
https://link.springer.com/article/10.1007/s12630-021-02173-1
DOI
10.1007/s12630-021-02173-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Koo, Bon-Nyeo(구본녀) ORCID logo https://orcid.org/0000-0002-3189-1673
Kim, Min Soo(김민수) ORCID logo https://orcid.org/0000-0001-8760-4568
Park, Jin Ha(박진하) ORCID logo https://orcid.org/0000-0002-1398-3304
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188337
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