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Effects of intraoperative dexmedetomidine infusion on renal function in elective living donor kidney transplantation: a randomized controlled trial

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dc.contributor.author곽영란-
dc.contributor.author구본녀-
dc.contributor.author김민수-
dc.contributor.author박진하-
dc.date.accessioned2022-05-09T17:01:18Z-
dc.date.available2022-05-09T17:01:18Z-
dc.date.issued2022-04-
dc.identifier.issn0832-610X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188337-
dc.description.abstractPurpose: Ischemia-reperfusion injury is inevitable during donor organ harvest and recipient allograft reperfusion in kidney transplantation, and affects graft outcomes. Dexmedetomidine, an α2-adrenoreceptor agonist, has renoprotective effects against ischemia-reperfusion injury. We investigated the effects of intraoperative dexmedetomidine infusion on renal function and the development of delayed graft function after elective living donor kidney transplantation in a randomized controlled trial. Methods: A total of 104 patients were randomly assigned to receive either an intraoperative infusion of dexmedetomidine 0.4 μg·kg-1·hr-1 or 0.9% saline. The primary outcome was the serum creatinine level on postoperative day (POD) 7. Secondary outcomes were renal function and the degree of inflammation and included the following variables: serum creatinine level and estimated glomerular filtration rate up to six months; incidence of delayed graft function; and levels of serum cystatin C, plasma interleukin (IL)-1β, and IL-18 during the perioperative period. Results: The mean (standard deviation) serum creatinine level on POD 7 was comparable between the groups (dexmedetomidine vs control: 1.11 [0.87] mg·dL-1 vs 1.06 [0.73] mg·dL-1; mean difference, 0.05; 95% confidence interval, -0.27 to 0.36; P = 0.77). Delayed graft function occurred in one patient in each group (odds ratio, 1.020; P > 0.99). There were no significant differences in the secondary outcomes between the groups (all P > 0.05). Conclusions: Intraoperative dexmedetomidine infusion did not produce any beneficial effects on renal function or delayed graft function in patients undergoing elective living donor kidney transplantation. Study registration: www. Clinicaltrials: gov (NCT03327389); registered 31 October 2017.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer New York-
dc.relation.isPartOfCANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHDexmedetomidine* / pharmacology-
dc.subject.MESHGlomerular Filtration Rate-
dc.subject.MESHHumans-
dc.subject.MESHKidney / physiology-
dc.subject.MESHKidney Transplantation*-
dc.subject.MESHLiving Donors-
dc.titleEffects of intraoperative dexmedetomidine infusion on renal function in elective living donor kidney transplantation: a randomized controlled trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine (마취통증의학교실)-
dc.contributor.googleauthorJin Ha Park-
dc.contributor.googleauthorBon-Nyeo Koo-
dc.contributor.googleauthorMin-Soo Kim-
dc.contributor.googleauthorDongkwan Shin-
dc.contributor.googleauthorYoung-Lan Kwak-
dc.identifier.doi10.1007/s12630-021-02173-1-
dc.contributor.localIdA00172-
dc.contributor.localIdA00193-
dc.contributor.localIdA00463-
dc.contributor.localIdA01704-
dc.relation.journalcodeJ00426-
dc.identifier.eissn1496-8975-
dc.identifier.pmid34931289-
dc.identifier.urlhttps://link.springer.com/article/10.1007/s12630-021-02173-1-
dc.subject.keywordbiomarkers-
dc.subject.keyworddelayed graft function-
dc.subject.keyworddexmedetomidine-
dc.subject.keywordkidney transplantation-
dc.subject.keywordrenal function-
dc.contributor.alternativeNameKwak, Young Lan-
dc.contributor.affiliatedAuthor곽영란-
dc.contributor.affiliatedAuthor구본녀-
dc.contributor.affiliatedAuthor김민수-
dc.contributor.affiliatedAuthor박진하-
dc.citation.volume69-
dc.citation.number4-
dc.citation.startPage448-
dc.citation.endPage459-
dc.identifier.bibliographicCitationCANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE, Vol.69(4) : 448-459, 2022-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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