Cited 4 times in
Effects of intraoperative dexmedetomidine infusion on renal function in elective living donor kidney transplantation: a randomized controlled trial
DC Field | Value | Language |
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dc.contributor.author | 곽영란 | - |
dc.contributor.author | 구본녀 | - |
dc.contributor.author | 김민수 | - |
dc.contributor.author | 박진하 | - |
dc.date.accessioned | 2022-05-09T17:01:18Z | - |
dc.date.available | 2022-05-09T17:01:18Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 0832-610X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188337 | - |
dc.description.abstract | Purpose: Ischemia-reperfusion injury is inevitable during donor organ harvest and recipient allograft reperfusion in kidney transplantation, and affects graft outcomes. Dexmedetomidine, an α2-adrenoreceptor agonist, has renoprotective effects against ischemia-reperfusion injury. We investigated the effects of intraoperative dexmedetomidine infusion on renal function and the development of delayed graft function after elective living donor kidney transplantation in a randomized controlled trial. Methods: A total of 104 patients were randomly assigned to receive either an intraoperative infusion of dexmedetomidine 0.4 μg·kg-1·hr-1 or 0.9% saline. The primary outcome was the serum creatinine level on postoperative day (POD) 7. Secondary outcomes were renal function and the degree of inflammation and included the following variables: serum creatinine level and estimated glomerular filtration rate up to six months; incidence of delayed graft function; and levels of serum cystatin C, plasma interleukin (IL)-1β, and IL-18 during the perioperative period. Results: The mean (standard deviation) serum creatinine level on POD 7 was comparable between the groups (dexmedetomidine vs control: 1.11 [0.87] mg·dL-1 vs 1.06 [0.73] mg·dL-1; mean difference, 0.05; 95% confidence interval, -0.27 to 0.36; P = 0.77). Delayed graft function occurred in one patient in each group (odds ratio, 1.020; P > 0.99). There were no significant differences in the secondary outcomes between the groups (all P > 0.05). Conclusions: Intraoperative dexmedetomidine infusion did not produce any beneficial effects on renal function or delayed graft function in patients undergoing elective living donor kidney transplantation. Study registration: www. Clinicaltrials: gov (NCT03327389); registered 31 October 2017. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer New York | - |
dc.relation.isPartOf | CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Dexmedetomidine* / pharmacology | - |
dc.subject.MESH | Glomerular Filtration Rate | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney / physiology | - |
dc.subject.MESH | Kidney Transplantation* | - |
dc.subject.MESH | Living Donors | - |
dc.title | Effects of intraoperative dexmedetomidine infusion on renal function in elective living donor kidney transplantation: a randomized controlled trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Jin Ha Park | - |
dc.contributor.googleauthor | Bon-Nyeo Koo | - |
dc.contributor.googleauthor | Min-Soo Kim | - |
dc.contributor.googleauthor | Dongkwan Shin | - |
dc.contributor.googleauthor | Young-Lan Kwak | - |
dc.identifier.doi | 10.1007/s12630-021-02173-1 | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A00193 | - |
dc.contributor.localId | A00463 | - |
dc.contributor.localId | A01704 | - |
dc.relation.journalcode | J00426 | - |
dc.identifier.eissn | 1496-8975 | - |
dc.identifier.pmid | 34931289 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s12630-021-02173-1 | - |
dc.subject.keyword | biomarkers | - |
dc.subject.keyword | delayed graft function | - |
dc.subject.keyword | dexmedetomidine | - |
dc.subject.keyword | kidney transplantation | - |
dc.subject.keyword | renal function | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | 곽영란 | - |
dc.contributor.affiliatedAuthor | 구본녀 | - |
dc.contributor.affiliatedAuthor | 김민수 | - |
dc.contributor.affiliatedAuthor | 박진하 | - |
dc.citation.volume | 69 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 448 | - |
dc.citation.endPage | 459 | - |
dc.identifier.bibliographicCitation | CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE, Vol.69(4) : 448-459, 2022-04 | - |
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