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Ki-67 and breast cancer prognosis: does it matter if Ki-67 level is examined using preoperative biopsy or postoperative specimen?

Authors
 Soon Bo Choi  ;  Jung Min Park  ;  Jee Hyun Ahn  ;  Jieon Go  ;  Jeeye Kim  ;  Hyung Seok Park  ;  Seung Il Kim  ;  Byeong-Woo Park  ;  Seho Park 
Citation
 BREAST CANCER RESEARCH AND TREATMENT, Vol.192(2) : 343-352, 2022-04 
Journal Title
BREAST CANCER RESEARCH AND TREATMENT
ISSN
 0167-6806 
Issue Date
2022-04
MeSH
Biomarkers, Tumor / metabolism ; Biopsy ; Breast Neoplasms* / diagnosis ; Breast Neoplasms* / metabolism ; Breast Neoplasms* / surgery ; Female ; Humans ; Ki-67 Antigen* / metabolism ; Postoperative Period ; Prognosis ; Receptor, ErbB-2 / metabolism ; Receptors, Estrogen / metabolism ; Receptors, Progesterone / metabolism
Keywords
Biopsy ; Breast cancer ; Ki-67 ; Prognosis ; Surgical specimen
Abstract
Purpose: This study aimed to identify the association between Ki-67 level and the prognosis of patients with breast cancer, regardless of the timing of Ki-67 testing (using preoperative biopsy vs. postoperative specimen).

Methods: A total of 4177 patients underwent surgery between January 2008 and December 2016. Immunohistochemical Ki-67 levels, using either preoperative (1673) or postoperative (2831) specimens, were divided into four groups using cutoff points of 10%, 15%, and 20%.

Results: Groups with higher-Ki-67 levels, in both the pre- and postoperative periods, showed significantly larger tumor size, higher grade, more frequent hormone receptor-negativity and human epidermal growth factor receptor 2 overexpression, and active adjuvant treatments than groups with lower-Ki-67 levels. High-Ki-67 levels were also significantly associated with poor survival, irrespective of the timing of specimen examination.

Conclusion: Despite the problems associated with Ki-67, Ki-67 level is an important independent prognostic factor, regardless of the timing of Ki-67 testing, i.e., preoperative or postoperative testing.
DOI
10.1007/s10549-022-06519-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Go, Jieon(고지언)
Kim, Seung Il(김승일)
Kim, Jee Ye(김지예) ORCID logo https://orcid.org/0000-0003-3936-4410
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
Park, Se Ho(박세호) ORCID logo https://orcid.org/0000-0001-8089-2755
Park, Jung Min(박정민)
Park, Hyung Seok(박형석) ORCID logo https://orcid.org/0000-0001-5322-6036
Ahn, Jee Hyun(안지현)
Choi, Soon Bo(최순보)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188312
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