0 100

Cited 0 times in

Ki-67 and breast cancer prognosis: does it matter if Ki-67 level is examined using preoperative biopsy or postoperative specimen?

DC Field Value Language
dc.contributor.author고지언-
dc.contributor.author김승일-
dc.contributor.author김지예-
dc.contributor.author박병우-
dc.contributor.author박세호-
dc.contributor.author박정민-
dc.contributor.author박형석-
dc.contributor.author안지현-
dc.contributor.author최순보-
dc.date.accessioned2022-05-09T16:59:02Z-
dc.date.available2022-05-09T16:59:02Z-
dc.date.issued2022-04-
dc.identifier.issn0167-6806-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188312-
dc.description.abstractPurpose: This study aimed to identify the association between Ki-67 level and the prognosis of patients with breast cancer, regardless of the timing of Ki-67 testing (using preoperative biopsy vs. postoperative specimen). Methods: A total of 4177 patients underwent surgery between January 2008 and December 2016. Immunohistochemical Ki-67 levels, using either preoperative (1673) or postoperative (2831) specimens, were divided into four groups using cutoff points of 10%, 15%, and 20%. Results: Groups with higher-Ki-67 levels, in both the pre- and postoperative periods, showed significantly larger tumor size, higher grade, more frequent hormone receptor-negativity and human epidermal growth factor receptor 2 overexpression, and active adjuvant treatments than groups with lower-Ki-67 levels. High-Ki-67 levels were also significantly associated with poor survival, irrespective of the timing of specimen examination. Conclusion: Despite the problems associated with Ki-67, Ki-67 level is an important independent prognostic factor, regardless of the timing of Ki-67 testing, i.e., preoperative or postoperative testing.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKluwer Academic-
dc.relation.isPartOfBREAST CANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHBiomarkers, Tumor / metabolism-
dc.subject.MESHBiopsy-
dc.subject.MESHBreast Neoplasms* / diagnosis-
dc.subject.MESHBreast Neoplasms* / metabolism-
dc.subject.MESHBreast Neoplasms* / surgery-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKi-67 Antigen* / metabolism-
dc.subject.MESHPostoperative Period-
dc.subject.MESHPrognosis-
dc.subject.MESHReceptor, ErbB-2 / metabolism-
dc.subject.MESHReceptors, Estrogen / metabolism-
dc.subject.MESHReceptors, Progesterone / metabolism-
dc.titleKi-67 and breast cancer prognosis: does it matter if Ki-67 level is examined using preoperative biopsy or postoperative specimen?-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorSoon Bo Choi-
dc.contributor.googleauthorJung Min Park-
dc.contributor.googleauthorJee Hyun Ahn-
dc.contributor.googleauthorJieon Go-
dc.contributor.googleauthorJeeye Kim-
dc.contributor.googleauthorHyung Seok Park-
dc.contributor.googleauthorSeung Il Kim-
dc.contributor.googleauthorByeong-Woo Park-
dc.contributor.googleauthorSeho Park-
dc.identifier.doi10.1007/s10549-022-06519-1-
dc.contributor.localIdA06255-
dc.contributor.localIdA00658-
dc.contributor.localIdA00984-
dc.contributor.localIdA01475-
dc.contributor.localIdA01524-
dc.contributor.localIdA06148-
dc.contributor.localIdA01753-
dc.contributor.localIdA06150-
dc.contributor.localIdA05769-
dc.relation.journalcodeJ00403-
dc.identifier.eissn1573-7217-
dc.identifier.pmid35025005-
dc.subject.keywordBiopsy-
dc.subject.keywordBreast cancer-
dc.subject.keywordKi-67-
dc.subject.keywordPrognosis-
dc.subject.keywordSurgical specimen-
dc.contributor.alternativeNameGo, Jieon-
dc.contributor.affiliatedAuthor고지언-
dc.contributor.affiliatedAuthor김승일-
dc.contributor.affiliatedAuthor김지예-
dc.contributor.affiliatedAuthor박병우-
dc.contributor.affiliatedAuthor박세호-
dc.contributor.affiliatedAuthor박정민-
dc.contributor.affiliatedAuthor박형석-
dc.contributor.affiliatedAuthor안지현-
dc.contributor.affiliatedAuthor최순보-
dc.citation.volume192-
dc.citation.number2-
dc.citation.startPage343-
dc.citation.endPage352-
dc.identifier.bibliographicCitationBREAST CANCER RESEARCH AND TREATMENT, Vol.192(2) : 343-352, 2022-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.