0 54

Cited 0 times in

Risk of Incident Dementia According to Glycemic Status and Comorbidities of Hyperglycemia: A Nationwide Population-Based Cohort Study

Authors
 Woo Jung Kim  ;  Seo Jung Lee  ;  Eun Lee  ;  Eun Young Lee  ;  Kyungdo Han 
Citation
 DIABETES CARE, Vol.45(1) : 134-141, 2022-01 
Journal Title
DIABETES CARE
ISSN
 0149-5992 
Issue Date
2022-01
MeSH
Adult ; Blood Glucose ; Cohort Studies ; Dementia* / epidemiology ; Humans ; Hyperglycemia* / epidemiology ; Risk Factors
Abstract
Objective: To investigate the risk of incident dementia according to fasting glucose levels and presence of comorbidities.

Research design and methods: Using a health insurance claims database and the results of biennial health examinations in South Korea, we selected 8,400,950 subjects aged ≥40 years who underwent health examinations in 2009-2010. We followed them until 2016. Subjects' baseline characteristics were categorized by presence of diabetes (yes/no) and glycemic status as normoglycemia, impaired fasting glucose (IFG), new-onset diabetes, or known diabetes (duration <5 years or ≥5 years). We estimated adjusted hazard ratios (aHRs) for dementia occurrence in each category.

Results: During the observation period of 48,323,729 person-years, all-cause dementia developed in 353,392 subjects (4.2%). Compared with normoglycemia, aHRs (95% CI) were 1.01 (1.01-1.02) in IFG, 1.45 (1.44-1.47) in new-onset diabetes, 1.32 (1.30-1.33) in known diabetes <5 years, and 1.62 (1.60-1.64) in known diabetes ≥5 years. We found that associations between ischemic heart disease and chronic kidney disease with incident dementia were affected by the presence of diabetes. Ischemic stroke showed a greater association with incident dementia than diabetes.

Conclusions: Mild degrees of hyperglycemia and presence of comorbidities were associated with incident dementia. Intervention during the prodromal stage of a chronic disease (e.g., prediabetes) could be considered for dementia prevention.
Full Text
https://diabetesjournals.org/care/article/45/1/134/138990/Risk-of-Incident-Dementia-According-to-Glycemic
DOI
10.2337/dc21-0957
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Woo Jung(김우정) ORCID logo https://orcid.org/0000-0002-4963-4819
Lee, Eun(이은) ORCID logo https://orcid.org/0000-0002-7462-0144
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188275
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links