Cited 12 times in
Risk of Incident Dementia According to Glycemic Status and Comorbidities of Hyperglycemia: A Nationwide Population-Based Cohort Study
DC Field | Value | Language |
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dc.contributor.author | 김우정 | - |
dc.contributor.author | 이은 | - |
dc.date.accessioned | 2022-05-09T16:54:37Z | - |
dc.date.available | 2022-05-09T16:54:37Z | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 0149-5992 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188275 | - |
dc.description.abstract | Objective: To investigate the risk of incident dementia according to fasting glucose levels and presence of comorbidities. Research design and methods: Using a health insurance claims database and the results of biennial health examinations in South Korea, we selected 8,400,950 subjects aged ≥40 years who underwent health examinations in 2009-2010. We followed them until 2016. Subjects' baseline characteristics were categorized by presence of diabetes (yes/no) and glycemic status as normoglycemia, impaired fasting glucose (IFG), new-onset diabetes, or known diabetes (duration <5 years or ≥5 years). We estimated adjusted hazard ratios (aHRs) for dementia occurrence in each category. Results: During the observation period of 48,323,729 person-years, all-cause dementia developed in 353,392 subjects (4.2%). Compared with normoglycemia, aHRs (95% CI) were 1.01 (1.01-1.02) in IFG, 1.45 (1.44-1.47) in new-onset diabetes, 1.32 (1.30-1.33) in known diabetes <5 years, and 1.62 (1.60-1.64) in known diabetes ≥5 years. We found that associations between ischemic heart disease and chronic kidney disease with incident dementia were affected by the presence of diabetes. Ischemic stroke showed a greater association with incident dementia than diabetes. Conclusions: Mild degrees of hyperglycemia and presence of comorbidities were associated with incident dementia. Intervention during the prodromal stage of a chronic disease (e.g., prediabetes) could be considered for dementia prevention. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Diabetes Association | - |
dc.relation.isPartOf | DIABETES CARE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Blood Glucose | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Dementia* / epidemiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyperglycemia* / epidemiology | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Risk of Incident Dementia According to Glycemic Status and Comorbidities of Hyperglycemia: A Nationwide Population-Based Cohort Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학교실) | - |
dc.contributor.googleauthor | Woo Jung Kim | - |
dc.contributor.googleauthor | Seo Jung Lee | - |
dc.contributor.googleauthor | Eun Lee | - |
dc.contributor.googleauthor | Eun Young Lee | - |
dc.contributor.googleauthor | Kyungdo Han | - |
dc.identifier.doi | 10.2337/dc21-0957 | - |
dc.contributor.localId | A04906 | - |
dc.contributor.localId | A03032 | - |
dc.relation.journalcode | J00721 | - |
dc.identifier.eissn | 1935-5548 | - |
dc.identifier.pmid | 34711638 | - |
dc.identifier.url | https://diabetesjournals.org/care/article/45/1/134/138990/Risk-of-Incident-Dementia-According-to-Glycemic | - |
dc.contributor.alternativeName | Kim, Woo Jung | - |
dc.contributor.affiliatedAuthor | 김우정 | - |
dc.contributor.affiliatedAuthor | 이은 | - |
dc.citation.volume | 45 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 134 | - |
dc.citation.endPage | 141 | - |
dc.identifier.bibliographicCitation | DIABETES CARE, Vol.45(1) : 134-141, 2022-01 | - |
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