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International Retrospective Cohort Study of Conversion Therapy for Stage IV Gastric Cancer 1 (CONVO-GC-1)

Authors
 Kazuhiro Yoshida  ;  Itaru Yasufuku  ;  Masanori Terashima  ;  Sun Young Rha  ;  Jae Moon Bae  ;  Guoxin Li  ;  Hitoshi Katai  ;  Masahiko Watanabe  ;  Yasuyuki Seto  ;  Sung Hoon Noh  ;  Han- Kwang Yang  ;  Jiafu Ji  ;  Hideo Baba  ;  Yuko Kitagawa  ;  Satoshi Morita  ;  Masahiko Nishiyama  ;  Yasuhiro Kodera 
Citation
 ANNALS OF GASTROENTEROLOGICAL SURGERY, Vol.6(2) : 227-240, 2021-10 
Journal Title
ANNALS OF GASTROENTEROLOGICAL SURGERY
Issue Date
2021-10
Keywords
adjuvant surgery ; chemotherapy ; conversion therapy ; gastric cancer ; metastatic gastric cancer
Abstract
Aim: Much attention has been paid to conversion therapy for stage IV gastric cancer, however, its operative comorbidities and survival benefit have not yet been clarified. CONVO-GC-1, an international retrospective cohort study, was designed to investigate the role of conversion surgery in Japan, Korea, and China.

Methods: The rate of operative complications was the primary endpoint and the overall survival (OS), according to the four-category criteria previously published (Gastric Cancer:19; 2016), was analyzed as the secondary endpoint.

Results: A total of 1206 patients underwent surgery after chemotherapy with curative intent. Operative complications were observed in 290 (24.0%) patients in all grades, including pancreatic fistula and surgical site infection. The median survival time (MST) of all resected patients was 36.7 mo (M) and those of R0, R1, and R2 resection were 56.6 M, 25.8 M, and 21.7 M, respectively. Moreover, the MST of R0 patients were 47.8 M, 116.7 M, 44.8 M in categories 1, 2, and 3, respectively, and not reached in category 4. Interestingly, the MST of P1 patients was as favorable as that of P0CY1 patients if R0 resection was achieved. The MST of patients with liver metastasis was also favorable regardless of the number of lesions, and the MST of patients with para-aortic lymph node (LN) No 16a1/b2 metastasis was not inferior to that of patients with para-aortic LN No 16a2/b1 metastasis.

Conclusion: Conversion therapy for stage IV gastric cancer is safe and could be a new therapeutic strategy to improve the survival of patients, especially those with R0 resection.
Files in This Item:
T202125856.pdf Download
DOI
10.1002/ags3.12515
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188224
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