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Type 2 immunity plays an essential role for murine model of allergic contact dermatitis with mixed type 1/type 2 immune response

Authors
 Jeyun Park  ;  Jae Won Lee  ;  Sung Hee Kim  ;  Jongwook Oh  ;  Won Seok Roh  ;  Soo Min Kim  ;  Chang Ook Park  ;  Min-Geol Lee  ;  Tae-Gyun Kim 
Citation
 JOURNAL OF DERMATOLOGICAL SCIENCE, Vol.104(2) : 122-131, 2021-11 
Journal Title
JOURNAL OF DERMATOLOGICAL SCIENCE
ISSN
 0923-1811 
Issue Date
2021-11
MeSH
Animals ; Antigens, Surface / metabolism ; Dendritic Cells / immunology* ; Dermatitis, Allergic Contact / genetics* ; Dermatitis, Allergic Contact / immunology* ; Dermatitis, Allergic Contact / pathology ; Disease Models, Animal ; Immunity / genetics ; Immunoglobulins / metabolism ; Interferon-gamma / genetics ; Interferon-gamma / immunology ; Interleukin-17 / genetics ; Interleukin-4 / genetics ; Interleukin-4 / immunology ; Lectins, C-Type / metabolism ; Mannose-Binding Lectins / metabolism ; Mice ; Oxazolone ; Receptors, Cytokine / metabolism ; Signal Transduction ; Skin / pathology ; T-Lymphocytes / metabolism ; Transcriptome
Keywords
Allergic contact dermatitis ; Contact hypersensitivity ; Dendritic cells ; Interleukin-4 ; Mixed type 1/type 2 immunity ; Oxazolone ; T cells
Abstract
Background: Both human and mouse allergic contact dermatitis (ACD) frequently demonstrates a combined type 1 and type 2 immune response. However, the relative importance of type 2 immunity in this setting has been incompletely understood yet.

Objective: To explore an effector function of type 2 immunity in ACD with mixed type 1/type 2 immune response.

Methods: Gene expression characteristics of contact hypersensitivity (CHS) model was examined by quantitative polymerase chain reaction. Cytokine profile of T cells was analyzed by flow cytometry. The involvement of type 2 immunity was assessed by antibody-mediated cytokine neutralization and cell depletion. The role of specific subset of cutaneous dendritic cells was evaluated using diphtheria toxin-induced cell-depleting mouse strains.

Results: Oxazolone-induced CHS revealed a combination of type 1/type 2 gene expression. The severity of oxazolone-induced CHS was ameliorated by neutralization of IL-4 but not of IFN-γ, indicating that type 2 immunity plays a dominant effector function in this mixed type 1/type 2 model. Mechanistically, type 2 effector immunity was mounted by CD301b+Langeirn- dermal dendritic cells in part through thymic stromal lymphopoietin-interleukin 7 receptor alpha signaling-dependent manner.

Conclusion: Our findings suggest the clinical rationale for targeting type 2 immunity as a relevant therapeutic strategy for the mixed immune phenotype of ACD.
Full Text
https://www.sciencedirect.com/science/article/pii/S0923181121002279
DOI
10.1016/j.jdermsci.2021.10.001
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Tae-Gyun(김태균) ORCID logo https://orcid.org/0000-0002-2116-4579
Park, Chang Ook(박창욱) ORCID logo https://orcid.org/0000-0003-3856-1201
Oh, Jongwook(오종욱)
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188208
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